基于查尔酮的芳氧基丙醇胺的合成及其降血糖活性
Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines.
作者信息
Satyanarayana M, Tiwari Priti, Tripathi Brajendra K, Srivastava A K, Pratap Ram
机构信息
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
出版信息
Bioorg Med Chem. 2004 Mar 1;12(5):883-9. doi: 10.1016/j.bmc.2003.12.026.
PMID:14980600
Abstract
A series of aryloxypropanolamines (5a-r) of different chalcones (3a-e) were synthesized and evaluated for antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models. Among them compounds 5a, g, m, o, p and r showed significant reduction in blood glucose levels in both SLM and STZ animal models.
摘要
合成了一系列由不同查耳酮（3a - e）衍生的芳氧基丙醇胺（5a - r），并在蔗糖负荷（SLM）和链脲佐菌素（STZ）诱导的糖尿病动物模型中评估其降血糖活性。其中，化合物5a、g、m、o、p和r在SLM和STZ动物模型中均显示出血糖水平显著降低。
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