2-甲基-3,4,5-三芳基-1H-吡咯在链脲佐菌素诱导的糖尿病大鼠模型和自发性糖尿病小鼠模型中的降血糖活性
Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ models.
作者信息
Goel Atul, Agarwal Nidhi, Singh Fateh V, Sharon Ashoke, Tiwari Priti, Dixit Manish, Pratap Ramendra, Srivastava Arvind K, Maulik Prakas R, Ram Vishnu J
机构信息
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
出版信息
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1089-92. doi: 10.1016/j.bmcl.2004.01.009.
Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phenyl-1H-pyrroles (3c, d and h) showed significant inhibition on postprandial hyperglycemia in normal rats post sucrose loaded. These compounds also showed lowering of plasma glucose level in STZ-induced diabetic rat model.
合成了多种3,4,5-三芳基吡咯，并在蔗糖负荷（SLM）和/或链脲佐菌素诱导（STZ）的糖尿病大鼠模型中评估了它们的体内抗高血糖活性。三种测试化合物，即2-甲基-4,5-二苯基-3-取代苯基-1H-吡咯（3c、d和h），在正常大鼠蔗糖负荷后对餐后高血糖有显著抑制作用。这些化合物在STZ诱导的糖尿病大鼠模型中也显示出血浆葡萄糖水平降低。
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