Goel Atul, Agarwal Nidhi, Singh Fateh V, Sharon Ashoke, Tiwari Priti, Dixit Manish, Pratap Ramendra, Srivastava Arvind K, Maulik Prakas R, Ram Vishnu J
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1089-92. doi: 10.1016/j.bmcl.2004.01.009.
Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phenyl-1H-pyrroles (3c, d and h) showed significant inhibition on postprandial hyperglycemia in normal rats post sucrose loaded. These compounds also showed lowering of plasma glucose level in STZ-induced diabetic rat model.
合成了多种3,4,5-三芳基吡咯，并在蔗糖负荷（SLM）和/或链脲佐菌素诱导（STZ）的糖尿病大鼠模型中评估了它们的体内抗高血糖活性。三种测试化合物，即2-甲基-4,5-二苯基-3-取代苯基-1H-吡咯（3c、d和h），在正常大鼠蔗糖负荷后对餐后高血糖有显著抑制作用。这些化合物在STZ诱导的糖尿病大鼠模型中也显示出血浆葡萄糖水平降低。
