Department of Pathology, Erasmus MC University Medical Centre Rotterdam, The Netherlands.
J Pathol. 2011 Aug;224(4):431-3. doi: 10.1002/path.2939.
Human germ cell tumours comprise a heterogeneous group of neoplasms which, based on pathobiological, genetic and clinical characteristics, can be subdivided into different entities. One of these subgroups relates to the so-called spermatocytic seminomas, benign tumours only found in the testis, preferentially in elderly men. Various developmental models for this type of germ cell tumour have been proposed and it is clear that spermatocytic seminoma has a pathogenesis independent from that of seminoma. A recent study examining expression of spermatogonial markers shows that spermatocytic seminomas are a heterogeneous group of tumours, with a supposed difference in origin, ie the majority from A(pale) or B spermatogonia, and a minority from A(dark) spermatogonia. However, this does not exclude an earlier cell of origin, possibly explaining the unique properties of this type of human germ cell tumour, with various counterparts in animals.
人类生殖细胞肿瘤包含一组异质性的肿瘤，根据其病理生物学、遗传和临床特征，可以分为不同的实体。其中一个亚组与所谓的精原细胞瘤有关，这是一种仅在睾丸中发现的良性肿瘤，多见于老年男性。对于这种生殖细胞肿瘤，已经提出了各种发育模型，很明显，精原细胞瘤的发病机制与精母细胞瘤不同。最近一项研究检查了精原细胞标记物的表达，表明精原细胞瘤是一组具有异质性的肿瘤，其起源可能存在差异，即大多数来自 A（苍白）或 B 精原细胞，少数来自 A（暗）精原细胞。然而，这并不能排除更早的起源细胞，这可能解释了这种类型的人类生殖细胞肿瘤的独特性质，在动物中有各种对应物。
