Bennett R M, Bong D M, Spargo B H
Am J Med. 1978 Dec;65(6):955-62. doi: 10.1016/0002-9343(78)90747-7.
A group of 20 patients with mixed connective tissue disease, followed for up to five years, was found to have a 55 per cent incidence of neuropsychiatric problems. An aseptic meningitis-like syndrome was the most common presentation and was rapidly responsive to corticosteroid therapy. Other findings were psychosis, convulsions, peripheral neuropathy, trigeminal neuropathy and cerebellar ataxia. An abnormal cerebrospinal fluid was found in five patients; mild pleocytosis, an increased protein content and a first phase colloidal gold curve were the main abnormalities. These neuropsychiatric problems have not been a cause of mortality in this group of patients with mixed connective tissue disease.
一组20例混合性结缔组织病患者，随访长达5年，发现神经精神问题的发生率为55%。无菌性脑膜炎样综合征是最常见的表现，对皮质类固醇治疗反应迅速。其他表现包括精神病、惊厥、周围神经病变、三叉神经病变和小脑共济失调。5例患者脑脊液异常；主要异常为轻度细胞增多、蛋白含量增加和第一期胶体金曲线异常。在这组混合性结缔组织病患者中，这些神经精神问题并非死亡原因。
