Department of Family Medicine, Pusan National University School of Medicine, Gyeongsangnam-do, South Korea.
Clin Chim Acta. 2011 Sep 18;412(19-20):1848-53. doi: 10.1016/j.cca.2011.06.023. Epub 2011 Jun 25.
Serum amylase has recently been shown to be associated with ghrelin and adiponectin as well as obesity. We investigated the relationship between total amylase and metabolic syndrome in adults.
4495 adults were enrolled. All subjects denied any medical history or status of a disorder that could influence their serum amylase. Anthropometry, metabolic risk factors and total amylase concentration were measured. Each participant was categorized into one of 4 subgroups according to their total amylase concentration. Multiple logistic regression analysis was used to assess the independent association between amylase concentration and metabolic syndrome. Receiver-operating characteristics (ROC) curves analyses were used for comparison of the diagnostic value of amylase and other biomarkers for metabolic syndrome.
The prevalence of metabolic syndrome by the National Cholesterol Education Program criteria was 13.4%, 15.3%, 19.3%, and 24.2% of those in the fourth, third, second, and lowest quartile of amylase concentration (P for trend <0.001). After adjusting for age, sex, and body mass index, the odds ratios of the lower quartiles were significantly higher compared to the fourth quartile for the presence of metabolic syndrome. In ROC curve analysis, amylase was similar to uric acid as a significant diagnostic indicator for metabolic syndrome, but it had lower diagnostic value than alanine aminotransferase, γ-glutamyltransferase or C-reactive protein.
Lower amylase concentration is associated with an increased prevalence of metabolic syndrome. Amylase may contribute to identifying metabolic syndrome, although further research is needed to understand the mechanism behind these associations.
最近的研究表明，血清淀粉酶与 ghrelin 和 adiponectin 以及肥胖有关。我们研究了成年人中总淀粉酶与代谢综合征之间的关系。
共纳入 4495 名成年人。所有受试者均否认有任何可能影响血清淀粉酶的疾病史或状态。测量了人体测量学、代谢风险因素和总淀粉酶浓度。根据总淀粉酶浓度，将每个参与者分为 4 个亚组之一。使用多因素逻辑回归分析评估淀粉酶浓度与代谢综合征之间的独立相关性。使用受试者工作特征（ROC）曲线分析比较淀粉酶和其他代谢综合征生物标志物的诊断价值。
根据国家胆固醇教育计划标准，代谢综合征的患病率分别为第四、第三、第二和最低四分位数组的 13.4%、15.3%、19.3%和 24.2%（趋势 P<0.001）。在校正年龄、性别和体重指数后，与第四四分位数相比，低四分位数的代谢综合征存在的比值比明显更高。在 ROC 曲线分析中，淀粉酶与尿酸一样，是代谢综合征的一个重要诊断指标，但与丙氨酸氨基转移酶、γ-谷氨酰转移酶或 C-反应蛋白相比，其诊断价值较低。
较低的淀粉酶浓度与代谢综合征的患病率增加有关。淀粉酶可能有助于识别代谢综合征，但需要进一步研究来了解这些关联背后的机制。
