Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
Indian J Dermatol Venereol Leprol. 2011 Jul-Aug;77(4):507-10. doi: 10.4103/0378-6323.82418.
Congenital melanocytic nevus (CMN) may rarely regress which may also be associated with a halo or vitiligo. We describe a 10-year-old girl who presented with CMN on the left leg since birth, which recently started to regress spontaneously with associated depigmentation in the lesion and at a distant site. Dermoscopy performed at different sites of the regressing lesion demonstrated loss of epidermal pigments first followed by loss of dermal pigments. Histopathology and Masson-Fontana stain demonstrated lymphocytic infiltration and loss of pigment production in the regressing area. Immunohistochemistry staining (S100 and HMB-45), however, showed that nevus cells were present in the regressing areas.
先天性黑色素细胞痣 (CMN) 可能很少会自行消退，并且可能与晕痣或白癜风有关。我们描述了一位 10 岁女孩，出生时左腿上就有 CMN，最近该痣开始自发消退，病变部位和远处部位都出现了色素脱失。对不同部位的消退性病变进行皮肤镜检查，显示表皮色素首先丢失，然后是真皮色素丢失。组织病理学和 Masson-Fontana 染色显示，在消退区域有淋巴细胞浸润和色素生成丧失。然而，免疫组织化学染色 (S100 和 HMB-45) 显示，在消退区域仍存在黑色素细胞。
