Department of Clinical Pathology, Daejeon Health Sciences College, 77-3 Gayang2-Dong, Dong-Gu, Daejeon 300-711, South Korea.
Phytother Res. 2012 Mar;26(3):462-4. doi: 10.1002/ptr.3529. Epub 2011 Jul 5.
Our previous report showed that quercetin 3-rhamnoside (Q3R) possessed antiviral activity against influenza A/WS/33 virus in vitro. The present study evaluated the effect of Q3R on influenza A/WS/33 virus infected mice. Mice orally treated with Q3R (6.25 mg/kg per dose) at 2 h before and once daily for 6 days after influenza virus infection showed significant decreases in weight loss, and decreased mortality. Lung virus titers of mice killed at 6 days after infection were about 2000 times lower than that of the placebo-treated control mice and about two times lower than that for the oseltamivir-treated mice. Furthermore, histological evaluation showed that administration of Q3R delayed the development and progression of pulmonary lesions. Therefore, Q3R could be an attractive lead for the development of antiviral agents against influenza virus.
我们之前的报告表明，槲皮素 3-鼠李糖苷（Q3R）具有抗流感 A/WS/33 病毒的体外抗病毒活性。本研究评估了 Q3R 对感染流感 A/WS/33 病毒的小鼠的影响。在感染流感病毒前 2 小时和感染后每天口服 Q3R（6.25mg/kg/剂量）6 天的小鼠体重减轻明显减少，死亡率降低。感染后 6 天处死的小鼠肺病毒滴度比安慰剂治疗组小鼠低约 2000 倍，比奥司他韦治疗组小鼠低约 2 倍。此外，组织学评估表明，Q3R 的给药可延缓肺损伤的发展和进展。因此，Q3R 可能是开发抗流感病毒抗病毒药物的有吸引力的先导化合物。
