孕期大量饮酒与死产和早产风险
Heavy prenatal alcohol exposure and risk of stillbirth and preterm delivery.
作者信息
Cornman-Homonoff Joshua, Kuehn Devon, Aros Sofía, Carter Tonia C, Conley Mary R, Troendle James, Cassorla Fernando, Mills James L
机构信息
Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
出版信息
J Matern Fetal Neonatal Med. 2012 Jun;25(6):860-3. doi: 10.3109/14767058.2011.587559. Epub 2011 Jul 5.
Abstract
We prospectively identified 96 women consuming at least 4 drinks/day during pregnancy by screening 9628 pregnant women. In these women with heavy prenatal alcohol use, there were three stillbirths and one preterm delivery; 98 matched nondrinking women had no stillbirths and two preterm births. Preterm rates did not differ significantly. The stillbirth rate was higher in the exposed group (p = 0.06). Additional investigation showed the stillbirth rate in the exposed population (3.1%) was significantly higher (p = 0.019) than the reported Chilean population rate (0.45%). Our data suggest that heavy alcohol consumption may increase the risk for stillbirth but not preterm delivery.
摘要
我们通过对9628名孕妇进行筛查，前瞻性地确定了96名在孕期每天至少饮用4杯酒的女性。在这些大量产前饮酒的女性中，有3例死产和1例早产；98名匹配的不饮酒女性没有死产情况，有2例早产。早产率没有显著差异。暴露组的死产率更高（p = 0.06）。进一步调查显示，暴露人群的死产率（3.1%）显著高于智利报告的人群死产率（0.45%）（p = 0.019）。我们的数据表明，大量饮酒可能会增加死产风险，但不会增加早产风险。
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