Yoon Ho-Kyoung, Kim Yong-Ku
Department of Psychiatry, College of Medicine, Korea University, Korea.
Nord J Psychiatry. 2012 Feb;66(1):14-8. doi: 10.3109/08039488.2011.593045. Epub 2011 Jul 5.
Previous studies have shown that patients with bipolar disorder (BD) tend to have altered immune system function. Several studies have reported that changes in interferon-gamma (IFN-γ) may play an important role in the development of BD.
To investigate the relationship between IFN-γ and BD, 156 patients with BD and 175 control subjects were genotyped for the IFN-γ +874A/T single nucleotide polymorphism.
We detected significant differences in the genotype distributions and allele frequencies of the IFN-γ +874A/T single nucleotide polymorphism (rs2430561) between patients with BD and normal controls. The T allele was found to be significantly more common among patients with BD than in controls. Additionally, significant differences in scores on the Young Mania Rating Scale (YMRS) were found between the three genotypes of this polymorphism.
Our results suggest that the IFN-γ +874A/T polymorphism may have important effects related to susceptibility to BD and that the T allele may be associated with an increased risk of developing BD.
先前的研究表明，双相情感障碍（BD）患者的免疫系统功能往往会发生改变。多项研究报告称，γ-干扰素（IFN-γ）的变化可能在双相情感障碍的发病过程中起重要作用。
为了研究IFN-γ与双相情感障碍之间的关系，对156例双相情感障碍患者和175例对照受试者进行了IFN-γ +874A/T单核苷酸多态性的基因分型。
我们检测到双相情感障碍患者与正常对照之间IFN-γ +874A/T单核苷酸多态性（rs2430561）的基因型分布和等位基因频率存在显著差异。发现T等位基因在双相情感障碍患者中比在对照中更为常见。此外，该多态性的三种基因型在杨氏躁狂量表（YMRS）得分上存在显著差异。
我们的结果表明，IFN-γ +874A/T多态性可能对双相情感障碍易感性有重要影响，且T等位基因可能与双相情感障碍发病风险增加有关。
