Durquet-Perelmann C, Schmitt C, Nonnenmacher H, Braunwald J, Bingen A, Keller F
Laboratoire de Virologie de la Faculté de Médecine, Strasbourg, France.
Pathol Biol (Paris). 1990 Sep;38(7):705-9.
Adult female mice were administered 17 beta-oestradiol at pharmacological dosages by subcutaneous injections. Histopathological examination revealed an increase in cells of the mononuclear lineage infiltrating the sinusoids of the liver. In vitro culture of Kupffer cells demonstrated that the treatment did not alter their antiviral properties but did rather induce an activation of their non-specific immune properties. This activation might be beneficial or deleterious for the infected host and must be discussed in each particular pathological process.
成年雌性小鼠通过皮下注射给予药理剂量的17β-雌二醇。组织病理学检查显示，浸润肝脏血窦的单核谱系细胞增多。库普弗细胞的体外培养表明，该处理并未改变其抗病毒特性，但确实诱导了其非特异性免疫特性的激活。这种激活对受感染宿主可能有益或有害，必须在每个特定的病理过程中进行讨论。
