Pereira C A, Steffan A M, Koehren F, Kirn A
Braz J Med Biol Res. 1985;18(4):527-31.
Mouse Hepatitis Virus type 3 (MHV3) multiplication in isolated murine Kupffer cells was partially inhibited by pretreatment of the cells with lipopolysaccharide (LPS). Supernatants of LPS-treated Kupffer cells contained large amounts of interferon. Inhibition of MHV3 multiplication was also observed when normal Kupffer cells were cultivated in a medium containing supernatants of LPS-treated Kupffer cells. In addition to the antiviral effect of the released interferon, there seems to be another effect of LPS, since Kupffer cells cultured in medium containing anti-interferon alpha beta antibodies were partially activated by LPS to inhibit MHV3 replication. The in vivo consequences of these effects for the local immunity of the liver against MHV3 infection are discussed.
用脂多糖（LPS）预处理分离的小鼠库普弗细胞后，3型小鼠肝炎病毒（MHV3）在其中的增殖受到部分抑制。经LPS处理的库普弗细胞的上清液中含有大量干扰素。当正常库普弗细胞在含有经LPS处理的库普弗细胞上清液的培养基中培养时，也观察到MHV3增殖受到抑制。除了释放的干扰素的抗病毒作用外，LPS似乎还有另一种作用，因为在含有抗αβ干扰素抗体的培养基中培养的库普弗细胞被LPS部分激活，从而抑制MHV3复制。本文讨论了这些效应在体内对肝脏针对MHV3感染的局部免疫的影响。
