新型神经肽作为孤儿 G 蛋白偶联受体的配体。
Novel neuropeptides as ligands of orphan G protein-coupled receptors.
机构信息
Department of Pharmacology, University of California Irvine, Irvine, CA 92697, United States.
出版信息
Curr Pharm Des. 2011;17(25):2626-31. doi: 10.2174/138161211797416110.
Neuropeptides control a wide spectrum of physiological functions. They are central to our understanding of brain functions. They exert their actions by interacting with specific G protein-coupled receptors. We however have not found all the neuropeptides that exist in organisms. The search for novel neuropeptides is thus of great interest as it will lead to a better understanding of brain function and disorders. In this review, we will discuss the historical as well as the current approaches to neuropeptide discovery, with a particular emphasis on the orphan GPCR-based strategies. We will also discuss two novel peptides, neuropeptide S and neuromedin S, as examples of the impact of neuropeptide discovery on our understanding of brain functions. Finally, the challenges facing neuropeptide discovery will be discussed.
神经肽控制着广泛的生理功能。它们是我们理解大脑功能的核心。它们通过与特定的 G 蛋白偶联受体相互作用来发挥作用。然而，我们尚未发现生物体中存在的所有神经肽。因此，寻找新的神经肽非常有趣，因为这将有助于我们更好地理解大脑功能和紊乱。在这篇综述中，我们将讨论神经肽发现的历史和当前方法，特别强调基于孤儿 GPCR 的策略。我们还将讨论两种新型肽，神经肽 S 和神经调节素 S，作为神经肽发现对我们理解大脑功能的影响的例子。最后，将讨论神经肽发现所面临的挑战。
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