Department of Dermatology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
J Dermatol. 2011 Jul;38(7):702-6. doi: 10.1111/j.1346-8138.2010.01166.x. Epub 2011 Jan 27.
Nocardiosis is caused by gram-positive aerobic actinomycetes that live in soil and are known to be responsible for opportunistic infections. The condition mostly affects the lung, brain or skin. Here, we present a 24-year-old Japanese woman who had had systemic lupus erythematosus since the age of 20 years, and lupus nephritis since the age of 23 years. She developed cutaneous lymph duct-type nocardiosis due to Nocardia araoensis while on immunosuppressant therapy. The patient had cutaneous findings from the right inguinal region to the right lower thigh and did not have lesions on the rest of the body. Minocycline and co-trimoxazole were co-administrated, and her condition improved. To our knowledge, this is the first case in which N. araoensis was detected by analysis on rRNA base sequence in skin lesions.
奴卡菌病是由革兰阳性需氧放线菌引起的，这些放线菌生活在土壤中，已知会导致机会性感染。这种疾病主要影响肺部、大脑或皮肤。在这里，我们介绍一位 24 岁的日本女性，她从 20 岁起患有系统性红斑狼疮，从 23 岁起患有狼疮性肾炎。她在接受免疫抑制剂治疗时，因感染了 Araoensis 奴卡菌而患上了皮肤淋巴管型奴卡菌病。患者的右腹股沟到右大腿下部有皮肤病变，而身体其他部位没有病变。米诺环素和复方磺胺甲噁唑联合使用，病情有所改善。据我们所知，这是首例通过对皮肤病变的 rRNA 碱基序列分析检测到 Araoensis 奴卡菌的病例。
