Department of Dermatology, Faculty of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain.
Photodermatol Photoimmunol Photomed. 2011 Aug;27(4):219-21. doi: 10.1111/j.1600-0781.2011.00600.x.
Erythema multiforme (EM) is a self-limited skin disease, characterized by the abrupt onset of symmetric red papules that may evolve into target lesions often precipitated by an infection. Photosensitive erythema multiforme (PEM) is a rare disorder characterized by the distribution of the lesions on sun-exposed areas. It has been described at the sites of sunburn, following episodes of polymorphic light eruption or herpes labialis and in association with drugs. To our knowledge, PEM photoinduced by selective serotonin reuptake inhibitors has not been reported. We describe a patient who had two consecutive episodes of PEM related to two different triggers: paroxetine and HSV infection. In the first episode, systemic photosensitivity was confirmed with the photobiological study. UVB-MED was decreased when the patient was taking paroxetine and did not change after its substitution for duloxetine. However, it became normal after the withdrawal of both drugs, suggesting a cross-reactivity reaction. The UVB photopatch test with paroxetine was positive. The second episode occurred after a herpes labialis relapse. At that time, UVB-MED was normal.
多形红斑（EM）是一种自限性皮肤病，其特征为突然出现对称的红色丘疹，可能发展为靶形病变，常由感染引发。光敏感多形红斑（PEM）是一种罕见的疾病，其特征为病变分布在暴露于阳光的部位。它曾在晒伤部位、多形性光疹发作后或唇疱疹发作后以及与药物相关的部位被描述过。据我们所知，由选择性 5-羟色胺再摄取抑制剂（SSRI）引起的 PEM 尚未被报道过。我们描述了一名患者，他经历了两次连续的 PEM 发作，与两个不同的诱因有关：帕罗西汀和 HSV 感染。在第一个发作中，光生物学研究证实了全身光敏性。当患者服用帕罗西汀时，UVB-MED 减少，而在改用度洛西汀后并未改变。然而，在停用两种药物后，它恢复正常，提示存在交叉反应性。帕罗西汀的 UVB 光贴试验呈阳性。第二次发作发生在唇疱疹复发后。当时，UVB-MED 正常。
