奥曲肽诱导的血小板减少症：一例报告。
Octreotide-induced thrombocytopenia: a case report.
作者信息
Rashidi Armin, Rizvi Nahid
机构信息
Department of Internal Medicine, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 410, Norfolk, VA 23507, USA.
出版信息
J Med Case Rep. 2011 Jul 5;5:286. doi: 10.1186/1752-1947-5-286.
INTRODUCTION
Thrombocytopenia is an extremely rare complication of octreotide therapy and can be life threatening in the setting of esophageal variceal bleeding. We report a case of octreotide-induced reversible thrombocytopenia in a 54-year-old Caucasian man with alcohol-induced cirrhosis and upper gastrointestinal bleeding.
CASE PRESENTATION
Our patient's platelet count dropped from 155,000/mm3 upon admission to 77,000/mm3 a few hours after initiation of octreotide therapy and stayed low until the drug's administration was discontinued. Significant recovery was achieved quickly after discontinuation of octreotide.
CONCLUSIONS
Thrombocytopenia is a rare but potentially serious side effect of octreotide therapy and may complicate esophageal variceal bleeding. Physicians should be vigilant in identifying this potentially serious condition.
引言
血小板减少症是奥曲肽治疗极为罕见的并发症，在食管静脉曲张破裂出血的情况下可能危及生命。我们报告一例54岁患有酒精性肝硬化和上消化道出血的白种男性，因奥曲肽诱发可逆性血小板减少症。
病例介绍
我们的患者血小板计数在入院时为155,000/mm³，在开始奥曲肽治疗后数小时降至77,000/mm³，并一直维持在低水平，直到停药。停药后血小板计数迅速显著恢复。
结论
血小板减少症是奥曲肽治疗罕见但潜在严重的副作用，可能使食管静脉曲张破裂出血复杂化。医生应警惕识别这种潜在的严重情况。
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