Li Feng, Duan Lian-Ning, Ji Shu-Quan
Department of Hematolgy, Chinese PLA Air Force General Hospital, Beijing 100142, China; The Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Jun;19(3):824-7.
Veto activity was defined as the capacity of specifically downregulating cytotoxic T-precursor cell (CTL-p) directed against antigens of the veto cells themselves but not against third-party antigens. Many studies have shown that the most potent veto cells are CD8(+) cytotoxic T lymphocytes (CD8(+)CTLs). Effectively, CD8(+)CTLs of donor origin can facilitate engraftment of donor's stem cells by eliminating host-alloreactive T lymphocytes. In this article, effect mechanisms, depletion of GVH ex vivo, application in vivo, synergistic enhancement with rapamycin and regulatory T cells, and anti-tumor effect in the hematopoietic stem cell transplantation are summarized.
否决活性被定义为特异性下调针对否决细胞自身抗原而非第三方抗原的细胞毒性T前体细胞（CTL-p）的能力。许多研究表明，最有效的否决细胞是CD8(+)细胞毒性T淋巴细胞（CD8(+)CTLs）。实际上，供体来源的CD8(+)CTLs可通过清除宿主同种异体反应性T淋巴细胞来促进供体干细胞的植入。本文总结了其作用机制、体外GVH清除、体内应用、与雷帕霉素和调节性T细胞的协同增强作用以及在造血干细胞移植中的抗肿瘤作用。
