Virginia G. Piper Cancer Center, Scottsdale Healthcare, 10510 N. 92nd Street, Scottsdale, AZ 85258, USA.
Clin Breast Cancer. 2011 Aug;11(4):268-9. doi: 10.1016/j.clbc.2010.11.001. Epub 2011 May 3.
Breast cancer at age 21 is rare, even in individuals who have a genetic predisposition. These early diagnoses are usually the result of a hereditary cancer syndrome. Other contributing factors, such as chemotherapy and radiation for previous malignancies, can also increase the risk of secondary malignancies, including breast cancer. Here we present one of the youngest cases of breast cancer reported in the literature: a 21-year-old Wilms' tumor survivor (diagnosed at age 6), who was found to have a familial BRCA1 mutation and was diagnosed with ductal carcinoma in situ at age 21.
21 岁患乳腺癌极为罕见，即使患者有遗传易感性也是如此。这些早期诊断通常是遗传性癌症综合征的结果。其他促成因素，如先前恶性肿瘤的化疗和放疗，也会增加继发性恶性肿瘤（包括乳腺癌）的风险。在此，我们报告了文献中报道的最年轻的乳腺癌病例之一：一名 21 岁的 Wilms 瘤幸存者（6 岁时确诊），她被发现存在家族性 BRCA1 突变，并在 21 岁时被诊断为导管原位癌。
