McCarty E J, Quah S, Maw R, Dinsmore W W, Emerson C R
Department of Genitourinary Medicine, Royal Victoria Hospital, Belfast, UK.
Int J STD AIDS. 2011 Jul;22(7):407-8. doi: 10.1258/ijsa.2009.009463.
An audit of 72 patients presenting for post-exposure prophylaxis following sexual exposure (PEPSE) to HIV (68 genitourinary medicine and 4 accident & emergency) was conducted from 2003 to 2009. The principal indications for PEPSE included 27 (38%) unprotected intercourse (15/27 vaginal and 12/27 anal) with a known HIV-positive partner, 20 (28%) unprotected receptive anal sex with male partner of unknown status, 17 (24%) following sexual assault and three (4%) unprotected sex with a partner from an endemic country. Of those who commenced PEPSE, 92% did so within the recommended 72 hours. Concurrent sexually transmitted infection (STI) was diagnosed in 8.3% patients (6.9% non-gonococcal urethritis and 1.4% rectal chlamydia). Fifty (69%) patients attended for follow-up and only 8% of these did not complete treatment. Twenty-five (35%) patients attended for repeat serology at three months and 18 (25%) at six months. All of the patients followed up remained HIV-negative.
2003年至2009年期间，对72名因性接触暴露于艾滋病毒后进行暴露后预防（PEPSE）的患者进行了审计（68名在泌尿生殖医学科，4名在急诊科）。PEPSE的主要指征包括：与已知艾滋病毒阳性伴侣发生27次（38%）无保护性交（15/27为阴道性交，12/27为肛交）；与身份不明的男性伴侣发生20次（28%）无保护的接受性肛交；17次（24%）遭受性侵犯后；以及与来自艾滋病流行国家的伴侣发生3次（4%）无保护性交。在开始PEPSE的患者中，92%在推荐的72小时内开始。8.3%的患者被诊断出同时患有性传播感染（STI）（6.9%为非淋菌性尿道炎，1.4%为直肠衣原体感染）。50名（69%）患者前来随访，其中只有8%未完成治疗。25名（35%）患者在三个月时前来进行重复血清学检测，18名（25%）在六个月时前来检测。所有接受随访的患者艾滋病毒检测仍为阴性。
