Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA,
AIDS Behav. 2014 Feb;18(2):217-25. doi: 10.1007/s10461-013-0567-0.
To characterize adherence to post-exposure prophylaxis after non-forcible sexual exposure to HIV, we conducted a review of the literature and meta-analysis. Articles were considered if they contained primary adherence data following non-forcible sexual exposure. Random-effects meta-analysis was used to create pooled point estimates for adherence. Of 1,257 abstracts identified through our search algorithm, 17 were eligible for inclusion in this review, representing 3,634 patients enrolled in 3 randomized controlled trials (RCTs), 9 prospective and 5 retrospective observational studies. Pooled adherence, primarily assessed by self-report, was 77 % [95 % confidence interval (CI) 68-87] in prospective observational studies, 81 % (95 % CI 65-96) in retrospective studies, 78 % (95 % CI 65-91) in RCTs, and 78 % (95 % CI 72-85) overall. Overall adherence was moderately high, with high variability between studies. Assessment of adherence could be enhanced by the use of objective measurements.
为了描述非强迫性性接触后 HIV 暴露后预防（PEP）的依从性，我们进行了文献回顾和荟萃分析。如果文章包含非强迫性性接触后的主要依从性数据，则将其视为符合条件。采用随机效应荟萃分析来创建依从性的汇总点估计值。通过我们的搜索算法，共识别出 1257 篇摘要，其中 17 篇符合纳入本综述的标准，代表了 3634 名参加 3 项随机对照试验（RCT）、9 项前瞻性和 5 项回顾性观察性研究的患者。主要通过自我报告评估的依从性汇总值为：前瞻性观察性研究中为 77%[95%置信区间（CI）68-87]，回顾性研究中为 81%（95%CI 65-96），RCT 中为 78%（95%CI 65-91），总体为 78%（95%CI 72-85）。总体依从性较高，但研究间差异较大。通过使用客观测量方法，可以提高依从性评估的准确性。
