Holwitt E A, Koda E, Swenberg C E
Radiation Biochemistry Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20814-5145.
Radiat Res. 1990 Oct;124(1):107-9.
The radioprotector WR-33278, the disulfide of WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane), is shown to stimulate eukaryotic topoisomerase I unwinding of negatively supercoiled DNA. This observation suggests the possibility that some protection may be conferred to DNA either by a decrease in its supercoiled state or by altering directly other enzymatic processes. This is the first report of a radioprotective compound stimulating an enzyme involved in DNA structure and synthesis.
辐射防护剂WR-33278是WR-1065（N-（2-巯基乙基）-1,3-二氨基丙烷）的二硫化物，已证明它能刺激真核拓扑异构酶I解开负超螺旋DNA。这一观察结果表明，有可能通过降低DNA的超螺旋状态或直接改变其他酶促过程来为DNA提供某种保护。这是关于一种辐射防护化合物刺激参与DNA结构和合成的酶的首次报道。
