Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden.
J Am Coll Nutr. 2011 Apr;30(2):134-40. doi: 10.1080/07315724.2011.10719952.
The objective of this study was to examine the association of birth weight (BW) with body composition, resting metabolic rate (RMR), nonprotein respiratory quotient (NPRQ), and insulin sensitivity changes after a 12-week diet intervention program.
A total of 78 obese (body mass index [BMI] 34.0 ± 2.8) women aged 36.7 ± 7 years volunteered to participate in a 12-week diet intervention program. We assessed body fat mass (FM), lean mass (LM), and bone mass (BM; measured by dual energy x-ray absorptiometry), RMR (measured by indirect calorimetry), fasting plasma glucose, and insulin before and after the intervention. We calculated BMI, FM to LM ratio (FM/LM), and HOMA-IR. BW and gestational age were self-reported, and the BW Z-score was calculated.
At baseline, the BW Z-score was positively associated with LM (p < 0.01) and RMR (p < 0.05). The BW Z-score was significantly associated with diet-induced FM (p < 0.05) and FM/LM ratio changes (p < 0.01) independently of potential confounders including weight loss. The BW Z-score was not associated with diet-induced RMR or insulin resistance changes.
Lower birth weight is associated with lower LM and RMR in obese women and could program a lower FM loss achievement after an energy-restriction diet intervention.
本研究旨在探讨出生体重（BW）与身体成分、静息代谢率（RMR）、非蛋白呼吸商（NPRQ）以及 12 周饮食干预后胰岛素敏感性变化的关系。
共有 78 名肥胖（体重指数[BMI]34.0±2.8）、年龄 36.7±7 岁的女性自愿参加了为期 12 周的饮食干预计划。我们评估了身体脂肪量（FM）、瘦体重（LM）和骨量（BM；通过双能 X 射线吸收法测量）、RMR（通过间接热量法测量）、空腹血糖和干预前后的胰岛素。我们计算了 BMI、FM 与 LM 比值（FM/LM）和 HOMA-IR。BW 和胎龄由自我报告，BW Z 评分计算得出。
在基线时，BW Z 评分与 LM（p<0.01）和 RMR（p<0.05）呈正相关。BW Z 评分与饮食引起的 FM（p<0.05）和 FM/LM 比值变化（p<0.01）显著相关，独立于体重减轻等潜在混杂因素。BW Z 评分与饮食引起的 RMR 或胰岛素抵抗变化无关。
较低的出生体重与肥胖女性的 LM 和 RMR 较低有关，并且可能会影响能量限制饮食干预后 FM 减少的效果。
