Maharjan Radha, Nagar Padamnabhi S, Nampoothiri Laxmipriya
Department of Biochemistry, M.S. University of Baroda, Vadodara, Gujarat, India.
J Ayurveda Integr Med. 2010 Oct;1(4):273-9. doi: 10.4103/0975-9476.74090.
This is a preliminary study that explores the efficacy of Aloe vera gel formulation as a possible therapeutic agent in the prevention and management of polycystic ovary syndrome (PCOS). PCOS is recognized as the most common endocrinopathy of women. Increased androgen synthesis, disrupted folliculogenesis, and insulin resistance lie at the patho-physiological core of PCOS. Current therapy for such a syndrome is use of insulin sensitizers. Large randomized clinical trials of metformin as the insulin-sensitizing drug, however, suggested that it produces many side effects after prolonged usage. For this reason, an alternate therapy would be to use herbs with hypoglycemic potential. Aloe barbadensis Mill. (Liliaceae) popularly known as Aloe vera is a well-known plant with such properties. The present study evaluated the efficacy of Aloe vera gel formulation in a PCOS rat model. Five month old Charles Foster female rats were orally fed with letrozole, a non-steroidal aromatase inhibitor, to induce PCOS. The rats were then treated orally with the Aloe vera gel formulation (1 ml dose daily for 45 days). This restored their estrus cyclicity, glucose sensitivity, and steroidogenic activity. Co-treatment of the inductive agent (letrozole) with the Aloe vera gel prevented the development of the PCO phenotype. Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by restoring the ovarian steroid status, and altering key steroidogenic activity. This can be attributed to phyto-components present in the extract.
这是一项初步研究，旨在探索芦荟凝胶制剂作为一种可能的治疗剂在预防和管理多囊卵巢综合征（PCOS）方面的疗效。PCOS被认为是女性最常见的内分泌疾病。雄激素合成增加、卵泡发生紊乱和胰岛素抵抗是PCOS病理生理的核心。目前针对这种综合征的治疗方法是使用胰岛素增敏剂。然而，作为胰岛素增敏药物的二甲双胍的大型随机临床试验表明，长期使用后会产生许多副作用。因此，另一种治疗方法是使用具有降血糖潜力的草药。库拉索芦荟（百合科），俗称芦荟，就是一种具有此类特性的著名植物。本研究评估了芦荟凝胶制剂在PCOS大鼠模型中的疗效。给5个月大的查尔斯·福斯特雌性大鼠口服非甾体芳香化酶抑制剂来曲唑以诱导PCOS。然后给这些大鼠口服芦荟凝胶制剂（每天1毫升剂量，持续45天）。这恢复了它们的发情周期、葡萄糖敏感性和类固醇生成活性。诱导剂（来曲唑）与芦荟凝胶联合治疗可预防PCO表型的发展。芦荟凝胶制剂通过恢复卵巢类固醇状态和改变关键的类固醇生成活性，对PCOS表型发挥保护作用。这可归因于提取物中存在的植物成分。
