Savarikar Shreeram S, Barbhind Maneesha M, Halde Umakant K, Kulkarni Alpana P
Department of Rasashastra, R. A. Potdar Medical College, Mumbai, Maharashtra, India.
J Ayurveda Integr Med. 2011 Jan;2(1):21-5. doi: 10.4103/0975-9476.78187.
Development of standardized, synergistic, safe and effective traditional herbal formulations with robust scientific evidence can offer faster and more economical alternatives for the treatment of disease. The main objective was to develop a method of preparation of guggulkalpa tablets so that the tablets meet the criteria of efficacy, stability, and safety.
Triphalaguggulkalpa tablet, described in sharangdharsanhita and containing guggul and triphala powder, was used as a model drug. Preliminary experiments on marketed triphalaguggulkalpa tablets exhibited delayed in vitro disintegration that indicated probable delayed in vivo disintegration. The study involved preparation of triphalaguggulkalpa tablets by Ayurvedic text methods and by wet granulation, dry granulation, and direct compression method. The tablets were evaluated for loss on drying, volatile oil content, % solubility, and steroidal content. The tablets were evaluated for performance tests like weight variation, disintegration, and hardness.
It was observed that triphalaguggulkalpa tablets, prepared by direct compression method, complied with the hardness and disintegration tests, whereas tablets prepared by Ayurvedic text methods failed.
Direct compression is the best method of preparing triphalaguggulkalpa tablets.
开发具有充分科学依据的标准化、协同增效、安全有效的传统草药制剂，可为疾病治疗提供更快且更经济的选择。主要目标是开发一种制备古古勒卡尔帕片的方法，使该片剂符合疗效、稳定性和安全性标准。
选用《沙朗达尔医典》中描述的含有古古勒和三果药粉的三果古古勒卡尔帕片作为模型药物。对市售三果古古勒卡尔帕片进行的初步实验显示其体外崩解延迟，这表明体内崩解可能也会延迟。该研究涉及通过阿育吠陀文本方法以及湿法制粒、干法制粒和直接压片法制备三果古古勒卡尔帕片。对片剂进行干燥失重、挥发油含量、溶解度百分比和甾体含量的评估。对片剂进行重量差异、崩解和硬度等性能测试评估。
观察到，通过直接压片法制备的三果古古勒卡尔帕片符合硬度和崩解测试要求，而通过阿育吠陀文本方法制备的片剂未达标。
直接压片是制备三果古古勒卡尔帕片的最佳方法。
