Kamble Rachana, Sathaye Sadhana, Shah D P
University Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai-400 019, India.
Indian J Pharm Sci. 2008 May-Jun;70(3):368-72. doi: 10.4103/0250-474X.43005.
According to ayurvedic texts shodhan vidhi is an important process which enhances the biological activity of a compound and reduces the toxicity at the same time. Before incorporating into formulations, guggul is processed using Shodhan vidhi involving different shodhan dravyas like gulvel, gomutra, triphala, dashmul. We have evaluated the antispasmodic activity of guggul on ileum of guinea pig and Wistar rats. The animals were sacrificed and ileum tissue of guinea pig and rat was isolated and tested for antispasmodic activity using different spasmogens like acetylcholine, histamine and barium chloride. It was observed that the different shodhit guggul (shudha guggul) i.e. processed using different shodhan vidhi, showed good antispasmodic activity as compared to Ashudha guggul. When acetylcholine was used as spasmogen, gulvel and triphala shodhit guggul showed good antispasmodic activity than other shodhit guggul. Thus shodhan vidhi enhances the therapeutic properties of guggul.
根据阿育吠陀文献记载，净化疗法是一个重要过程，它能增强化合物的生物活性，同时降低毒性。在制成制剂之前，使用包括像印度醋栗、牛尿、三果木、十味药等不同净化药材的净化疗法来处理胶树脂。我们评估了胶树脂对豚鼠和Wistar大鼠回肠的解痉活性。处死动物后，分离出豚鼠和大鼠的回肠组织，并使用不同的致痉剂如乙酰胆碱、组胺和氯化钡来测试其解痉活性。观察到不同经过净化处理的胶树脂（纯净胶树脂），即使用不同净化疗法处理的胶树脂，与未净化的胶树脂相比，显示出良好的解痉活性。当使用乙酰胆碱作为致痉剂时，印度醋栗和三果木净化处理的胶树脂比其他经过净化处理的胶树脂表现出更好的解痉活性。因此，净化疗法增强了胶树脂的治疗特性。
