Brady M S, Coit D G
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Surg Gynecol Obstet. 1990 Nov;171(5):377-81.
Twenty-four patients underwent biopsy or resection of the liver for focal nodular hyperplasia (FNH) at Memorial Sloan-Kettering Cancer Center from 1978 to 1988. Twenty-two of the patients were women. The mean age was 35 years. A history of antecedent oral contraceptive or conjugated estrogen (Premarin) use was obtained in 18 of 21 women. There were two men, aged 26 and 37 years; neither gave a history of hormone use. Most of the tumors were solitary (22 of 24) and located in the left lobe of the liver (17 of 22). Fifteen of the patients had a prior or simultaneous malignant lesion and six had other benign tumors. Most of the tumors were resected with a wedge or subsegment of liver (13 of 24). Four patients underwent segmentectomy and five required lobectomy for removal of the tumors. Two patients had an intraoperative biopsy only. The patients in whom the tumor was diagnosed preoperatively underwent computed tomography and arteriography routinely. Scintigraphy of the liver with sulfur colloid was obtained in only three patients, despite its distinct potential for nonoperative diagnosis of FNH.
1978年至1988年期间，24例患者在纪念斯隆凯特琳癌症中心因局灶性结节性增生（FNH）接受了肝脏活检或切除术。其中22例为女性，平均年龄35岁。在21名女性患者中，有18名有口服避孕药或结合雌激素（普雷马林）的既往用药史。有两名男性，年龄分别为26岁和37岁，两人均无激素用药史。大多数肿瘤为单发（24例中的22例），位于肝左叶（22例中的17例）。15例患者有既往或同时存在的恶性病变，6例有其他良性肿瘤。大多数肿瘤通过楔形或肝亚段切除（24例中的13例）。4例患者接受了肝段切除术，5例需要肝叶切除术以切除肿瘤。2例患者仅接受了术中活检。术前诊断为肿瘤的患者常规接受了计算机断层扫描和动脉造影。尽管硫胶体肝闪烁显像对FNH有非手术诊断的明显潜力，但仅3例患者进行了该项检查。
