Nagorney D M
Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
World J Surg. 1995 Jan-Feb;19(1):13-8. doi: 10.1007/BF00316973.
Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HA) are uncommon benign hepatic tumors that continue to pose diagnostic and therapeutic challenges. An update of a recent Mayo Clinic experience is presented to highlight the management of patients harboring these neoplasms. A marked female predominance was seen. Incidental diagnosis was more prevalent with FNH, whereas symptomatic presentation was typical of HA. The frequency of oral contraceptive steroid use was similar regardless of tumor histology. Preoperative diagnosis remains difficult. Scintigraphy proved most specific, and ultrasonography and computed tomography were equally sensitive. Resection was employed in most patients. There was no mortality and minimal morbidity. Selective observation of FNH was uneventful, but resolution of HA after abstinence of oral contraceptive steroids was uncommon. These findings and data from the literature support selective management of benign liver tumors.
局灶性结节性增生（FNH）和肝细胞腺瘤（HA）是少见的肝脏良性肿瘤，它们在诊断和治疗方面仍存在挑战。本文介绍了梅奥诊所近期的经验更新，以突出对患有这些肿瘤患者的管理。结果显示女性明显居多。FNH以偶然诊断更为常见，而HA则以有症状表现为典型。无论肿瘤组织学类型如何，口服避孕药类固醇的使用频率相似。术前诊断仍然困难。闪烁扫描术被证明最具特异性，超声检查和计算机断层扫描的敏感性相当。大多数患者采用了手术切除。无死亡病例，发病率极低。对FNH进行选择性观察情况良好，但停用口服避孕药类固醇后HA消退的情况并不常见。这些发现以及文献数据支持对肝脏良性肿瘤进行选择性管理。
