Sasaki Y, Imaoka S, Shibata T, Ishikawa O, Iwanaga T, Kasugai H, Fujita M
Department of Surgery, Center for Adult Diseases, Osaka, Japan.
Surgery. 1990 Nov;108(5):840-6.
A new treatment method, interception of collaterals with a silicone rubber sheet, was applied to three patients with advanced hepatocellular carcinoma in whom arterial chemoembolization was assessed as ineffective because of the developed collateral feeding arteries. This procedure was followed by arterial chemoembolization or intraportal infusion chemotherapy or both. Follow-up celiac angiography confirmed that the long-term decollateralization was achieved by shielding the liver with silicone rubber sheeting. This technique resulted in partial responses without serious complications in all the patients including two who had no responses to chemoembolization before the procedure. The response durations were 5, 21, and 27, months, respectively. One patient died of gastrointestinal bleeding 7 months after the decollateralization. The other two patients are still alive, and the survivals after the procedure are 28 and 30 months, respectively. This therapy is considered promising and may be worth choosing as an adjuvant treatment for advanced hepatic malignancies uncontrolled by arterial chemotherapy or chemoembolization.
一种新的治疗方法，即使用硅橡胶片阻断侧支循环，应用于3例晚期肝细胞癌患者，这些患者因出现侧支供血动脉而被评估为动脉化疗栓塞无效。该操作之后进行动脉化疗栓塞或门静脉内灌注化疗或两者兼施。随访的腹腔动脉造影证实，通过用硅橡胶片覆盖肝脏实现了长期去侧支循环。该技术在所有患者中均产生了部分缓解，且无严重并发症，包括2例在该操作前对化疗栓塞无反应的患者。缓解持续时间分别为5个月、21个月和27个月。1例患者在去侧支循环7个月后死于胃肠道出血。另外2例患者仍然存活，术后生存期分别为28个月和30个月。这种治疗方法被认为很有前景，可能值得作为对动脉化疗或化疗栓塞无法控制的晚期肝脏恶性肿瘤的辅助治疗方法来选择。
