INSERM, Versailles, France.
Biogerontology. 2011 Dec;12(6):503-15. doi: 10.1007/s10522-011-9346-3. Epub 2011 Jul 6.
The capacity to regenerate cell compartments through cell proliferation is an important characteristic of many developed metazoan tissues. Pre- and post-natal development proceeds through the modifications occurring during cell division. Experiments with cultivated cells showed that cell proliferation originates changes in cell functions and coordinations that contribute to aging and senescence. The implications of the finite cell proliferation to aging of the organism is not the accumulation of cells at the end of their life cycle, but rather the drift in cell function created by cell division. Comparative gerontology shows that the regulation of the length of telomeres has no implications for aging. On the other hand there are interspecies differences in regard to the somatic cell division potential that seem to be related with the "plasticity" of the genome and with longevity, which should be viewed independently of the aging phenomenon. Telomeres may play a role in this plasticity through the regulation of chromosome recombination, and via the latter also in development.
通过细胞增殖来再生细胞隔室的能力是许多已分化后生动物组织的重要特征。出生前和出生后的发育是通过细胞分裂过程中发生的改变进行的。对培养细胞的实验表明，细胞增殖起源于细胞功能和协调的变化，这些变化导致衰老和衰老。有限的细胞增殖对生物体衰老的影响不是细胞在生命周期结束时的积累，而是细胞分裂造成的细胞功能漂移。比较老年学表明，端粒长度的调节与衰老无关。另一方面，种间在体细胞分裂潜能方面存在差异，这似乎与基因组的“可塑性”和寿命有关，而这两者应独立于衰老现象来看待。端粒可能通过调节染色体重组在这种可塑性中发挥作用，通过后者也在发育中发挥作用。
