Wohlsein P, Baumgärtner W, Kreipe H H, Haverich A, Hori A, Stan A C
Institut für Pathologie, Tierärztliche Hochschule Hannover, Hannover, Deutschland.
Pathologe. 2011 Sep;32(5):406-10. doi: 10.1007/s00292-011-1452-0.
Classic rabies is a progressive and lethal infectious disease of animals, which may be transmitted to humans. Inter-human infections are extremely rare. The present case describes transmittal of rabies virus by lung transplantation from an infected donor. Histologically, a lymphocytic encephalomyelitis with neuronal cytoplasmic inclusion bodies was found. Immunohistochemically, rabies virus antigen was detected in the central, autonomous and peripheral nervous system. By means of electron microscopy, virions were demonstrated in the brain. A central task of health care in transplantations is the detection of uncommon infectious agents and the prevention of their transmittal.
经典狂犬病是一种侵袭动物且具有致死性的进行性传染病，可传染给人类。人与人之间的感染极为罕见。本病例描述了通过肺移植由受感染供体传播狂犬病病毒的情况。组织学检查发现伴有神经元胞质内包涵体的淋巴细胞性脑脊髓炎。免疫组织化学检查在中枢、自主和周围神经系统中检测到狂犬病病毒抗原。通过电子显微镜在脑中证实了病毒粒子的存在。移植医疗保健的一项核心任务是检测罕见的传染因子并防止其传播。
