The National Institute for Health Research Biomedical Research Unit for Musculoskeletal Disease at University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Osteoporos Int. 2012 Jan;23(1):59-65. doi: 10.1007/s00198-011-1701-3. Epub 2011 Jul 6.
Vertebral fracture assessment (VFA) with densitometric devices uses less radiation than spinal radiography. We assessed risk of new vertebral fracture (VF) in women with baseline fracture identified on VFA using algorithm-based qualitative diagnosis. Women with VF had significantly greater risk of VF after 6 years compared to those without baseline fracture.
Prevalent VFs predict future fracture and are identifiable on vertebral fracture assessment (VFA) using bone densitometry devices. We have previously performed cross-sectional, but not longitudinal, VFA using the algorithm-based qualitative method (ABQ). We aimed to examine the prevalence and incidence of VF and test the association between prevalent and incident VF identified by ABQ VFA.
We used ABQ to assess vertebral images obtained at baseline and 6 years (Hologic devices) in 674 women at ages 39 to 80 years participating in the Osteoporosis and Ultrasound Study. Criteria for prevalent and incident VF were endplate fracture, with/without cortical fracture. We compared proportions (chi-squared test) and characteristics (two-sample t tests and analysis of variance) of women with and without VF and calculated odds ratios for incident VF in women with prevalent VF (logistic regression).
Prevalent VF was identified in one premenopausal woman and 41 postmenopausal women. Incident VF was identified in 18 postmenopausal women. Odds ratios (95% CI) for incident VF in postmenopausal women with prevalent VF were 7.8 (2.8, 22.1) (unadjusted) and 4.3 (1.4, 13.7) (adjusted for age and bone mineral density, BMD). Women with prevalent or incident VF were older (P < 0.01), with lower hip BMD (P < 0.001) compared to women without VF.
Population-based postmenopausal women had relatively low prevalence and incidence of VF analysed with the ABQ method applied to VFA. Women with prevalent fracture had a significantly greater risk of incident VF than women without prevalent fracture.
与脊柱 X 光相比，使用密度仪进行椎体骨折评估 (VFA) 的辐射量更少。我们使用基于算法的定性诊断对基线 VFA 中已识别出骨折的女性进行新椎体骨折 (VF) 的风险评估。与基线无骨折的女性相比，VF 后 6 年 VF 风险显著增加。
已发生的 VF 可预测未来骨折，并且可以使用骨密度仪设备在椎体骨折评估 (VFA) 中识别。我们之前已经使用基于算法的定性方法 (ABQ) 进行了横断面但不是纵向 VFA。我们旨在检查 VF 的患病率和发生率，并测试 ABQ VFA 识别的现患和新发 VF 之间的关联。
我们使用 ABQ 评估了在年龄为 39 至 80 岁之间参加骨质疏松症和超声研究的 674 名女性基线和 6 年（Hologic 设备）时的椎体图像。现患和新发 VF 的标准为终板骨折，伴/不伴皮质骨折。我们比较了有和无 VF 的女性的比例（卡方检验）和特征（两样本 t 检验和方差分析），并计算了在有现患 VF 的女性中发生 VF 的优势比（逻辑回归）。
1 名绝经前妇女和 41 名绝经后妇女被诊断为现患 VF。18 名绝经后妇女被诊断为新发 VF。绝经后女性中现患 VF 发生新发 VF 的比值比（95%CI）为 7.8（2.8，22.1）（未调整）和 4.3（1.4，13.7）（调整年龄和骨密度，BMD）。与无 VF 的女性相比，现患或新发 VF 的女性年龄更大（P < 0.01），髋部 BMD 更低（P < 0.001）。
使用 ABQ 方法对 VFA 进行分析，基于人群的绝经后女性现患和新发 VF 的发生率相对较低。与现患骨折的女性相比，无现患骨折的女性发生新发 VF 的风险显著增加。
