State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
ACS Nano. 2011 Aug 23;5(8):6334-8. doi: 10.1021/nn201407h. Epub 2011 Jul 8.
A novel kind of versatile logic device has been constructed utilizing ion-tuned DNA/Ag fluorescent nanoclusters, with K(+) and H(+) as two inputs. A well-chosen hairpin DNA with a poly-C loop serves as the template for synthesizing two species of Ag nanoclusters. Several G-tracts and C-tracts on its two terminals enable the hairpin DNA to convert into the G-quadruplex and/or i-motif structures upon input of K(+) and H(+). Such a structural change remarkably influences the spectral behaviors of Ag nanoclusters. In particular, different species of Ag nanoclusters have distinct fluorescence responses to the input of K(+) and H(+). These unique features of DNA/Ag nanoclusters enable multiple logic operations via multichannel fluorescence output, indicating the versatility as a molecular logic device. By altering the specific sequence of the hairpin DNA, more logic gates can be constructed utilizing Ag nanoclusters.
一种新型的多功能逻辑器件已经利用离子调谐的 DNA/Ag 荧光纳米团簇构建而成，以 K(+)和 H(+)作为两个输入。一个带有聚-C 环的精心设计的发夹 DNA 用作合成两种 Ag 纳米团簇的模板。其两端的几个 G-链段和 C-链段使发夹 DNA 在输入 K(+)和 H(+)时能够转化为 G-四链体和/或 i- 基序结构。这种结构变化显著影响 Ag 纳米团簇的光谱行为。特别是，不同种类的 Ag 纳米团簇对 K(+)和 H(+)的输入具有不同的荧光响应。DNA/Ag 纳米团簇的这些独特特性使得通过多通道荧光输出进行多种逻辑运算成为可能，表明其作为分子逻辑器件的多功能性。通过改变发夹 DNA 的特定序列，可以利用 Ag 纳米团簇构建更多的逻辑门。
