实现钯催化γ-硼酸化烯丙基醋酸酯反应的化学选择性、区域选择性和立体选择性。
Achieving chemo-, regio-, and stereoselectivity in palladium-catalyzed reaction of γ-borylated allylic acetates.
机构信息
Chimie et Photonique Moléculaires, UMR CNRS 6510, Université Rennes 1, Campus de Beaulieu, 263 Avenue du Général Leclerc, F-35042 Rennes Cedex, France.
出版信息
Org Lett. 2011 Aug 5;13(15):4132-5. doi: 10.1021/ol201661s. Epub 2011 Jul 6.
PMID:21732645
Abstract
Three-carbon highly functionalized γ-borylated allylic acetates underwent a regio- and stereocontrolled Tsuji-Trost reaction in the presence of palladium complexes. An ipso substitution of the acetate with complete stereoretention of the chiral center was achieved, leading to vinylic boronates with enantiomeric excesses above 99%.
摘要
三种碳高度官能化的γ-硼酸化烯丙基乙酸酯在钯配合物的存在下进行区域和立体控制的 Tsuji-Trost 反应。乙酸盐的反位取代实现了手性中心的完全立体保留，得到了对映过量大于 99%的烯丙基硼酸酯。
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