Sexual and Reproductive Medicine Program, Urology Service, Department of Surgery, Department of Psychiatry and Behavioral Services, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
BJU Int. 2011 Nov;108(9):1485-9. doi: 10.1111/j.1464-410X.2010.10029.x. Epub 2011 Jul 6.
• To assess factors that predict penile curvature responses to intralesional verapamil (ILV) injection therapy for men with Peyronie's disease (PD).
• Men with PD for <1 year were assessed at baseline and after 3 months of bi-monthly ILV-injection therapy. Curvature was assessed at the time of maximum penile rigidity. • Univariate relationships were tested with correlation or chi-square analyses. • Multivariate analyses included logistic and linear regression. • We analysed curvature improvement, defined as a decrease of ≥10 ° from baseline. Additionally, the relationship between curvature outcomes and patient age and degree of baseline penile curvature were assessed.
• Data from 131 men were included and the rates of penile curvature change were:26% improved, 12% worsened, and 62% stable. • Age (r=-0.24, P < 0.01) and larger baseline penile curvature (r= 0.33, P < 0.01) were associated with improved curvature on univariate analysis. • On multivariate analysis (logistic regression), both age [odds ratio (OR) 0.93, P < 0.01, 95%CI 0.89-0.97] and larger baseline penile curvature (OR 1.07, P < 0.01, 95%CI 1.04-1.11) were associated with improvements in curvature after ILV-injection therapy. • Improvements in curvature were associated with age (≤40 years vs >40 years; OR 0.27, P < 0.05, 95%CI 0.10-0.75) and degree of penile curvature at baseline (≤30 ° vs >30 °; OR 9.12, P < 0.01, 95%CI 1.94-42.84) when dichotomized as indicated.
• Younger age and larger baseline penile curvature were predictive of favourable curvature outcomes. • Analysis of dichotomized variables suggests that age and baseline curvature thresholds may be important to consider when deciding on ILV as a therapeutic strategy for PD.
评估预测阴茎弯曲对接受腔内维拉帕米（ILV）注射治疗的男性的阴茎弯曲反应的因素。
对患有 PD 不到 1 年的男性在基线和每两个月接受 3 个月的 ILV 注射治疗后进行评估。在最大阴茎硬度时评估弯曲度。
用相关或卡方分析测试单变量关系。
多变量分析包括逻辑和线性回归。
我们分析了曲率改善，定义为与基线相比减少≥10°。此外，还评估了曲率结果与患者年龄和基线阴茎曲率程度之间的关系。
纳入了 131 名男性的数据，阴茎弯曲变化率为：26%改善，12%恶化，62%稳定。
年龄（r=-0.24，P<0.01）和更大的基线阴茎曲率（r=0.33，P<0.01）在单变量分析中与曲率改善相关。
多变量分析（逻辑回归）显示，年龄[优势比（OR）0.93，P<0.01，95%CI 0.89-0.97]和更大的基线阴茎曲率（OR 1.07，P<0.01，95%CI 1.04-1.11）均与 ILV 注射治疗后曲率的改善相关。
曲率的改善与年龄（≤40 岁与>40 岁；OR 0.27，P<0.05，95%CI 0.10-0.75）和基线阴茎曲率程度（≤30°与>30°；OR 9.12，P<0.01，95%CI 1.94-42.84）相关，当以二分法表示时。
年龄较小和更大的基线阴茎曲率是预测有利的曲率结果的因素。对二分变量的分析表明，年龄和基线曲率阈值可能在决定 ILV 作为 PD 的治疗策略时很重要。
