Randhawa Karen, Shukla C J
Western General Hospital, Edinburgh, UK.
Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK.
Ther Adv Urol. 2019 Feb 11;11:1756287218823671. doi: 10.1177/1756287218823671. eCollection 2019 Jan-Dec.
Peyronies disease (PD) is estimated to affect approximately 3-9% of men worldwide and maybe associated with pain, erectile dysfunction and penile deformity including shortening. The condition has significant debilitating effects on quality of life, self-esteem and psychological wellbeing in addition to sexual function. Surgical results add further to this by patients having dissatisfaction with various aspects of outcomes. Non-surgical management may allow patients to avoid the morbidities associated with surgery and still achieve improved functional and aesthetic outcomes. Several non-surgical options are currently being employed in the treatment of PD that may reduce or stabilize both objective measures (e.g. penile length and deformity) and subjective measures (including sexual function, pain and partner satisfaction). Nonsurgical management can allow patients to avoid the morbidities associated with surgery and still achieve improved functional and aesthetic outcomes. In this article we explore the current non-surgical management options for PD including oral, mechanical therapies, intralesional and topical treatments. We also briefly discuss future treatment options in the form of stem cell therapy.
佩罗尼氏病（PD）据估计影响全球约3%至9%的男性，可能与疼痛、勃起功能障碍以及包括阴茎缩短在内的阴茎畸形有关。除性功能外，该病症对生活质量、自尊和心理健康有显著的削弱作用。手术结果更是雪上加霜，患者对手术结果的各个方面都不满意。非手术治疗或许能让患者避免与手术相关的并发症，同时仍能实现功能和美观方面的改善。目前有几种非手术方法用于治疗佩罗尼氏病，这些方法可能会降低或稳定客观指标（如阴茎长度和畸形）以及主观指标（包括性功能、疼痛和伴侣满意度）。非手术治疗能让患者避免与手术相关的并发症，同时仍能实现功能和美观方面的改善。在本文中，我们探讨了目前针对佩罗尼氏病的非手术治疗方法，包括口服、机械疗法、病灶内和局部治疗。我们还简要讨论了干细胞疗法形式的未来治疗选择。
