King's College London, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK.
Psychol Med. 2011 Dec;41(12):2507-13. doi: 10.1017/S003329171100078X. Epub 2011 Jun 7.
It has been suggested that childhood obsessive-compulsive disorder (OCD) may be a risk factor for the development of an eating disorder (ED) later in life, but prospective studies are lacking. We aimed to determine the prevalence of ED at follow-up and clinical predictors in a longitudinal clinical sample of adolescents/young adults diagnosed with OCD in childhood.
All contactable (n=231) young people with OCD assessed over 9 years at a national and specialist paediatric OCD clinic were included in this study. At follow-up, 126 (57%) young people and parents completed the ED section of the Developmental and Well-being Assessment. Predictors for ED were investigated using logistic regression.
In total, 16 participants (12.7%) had a diagnosis of ED at follow-up. Having an ED was associated with female gender and persistent OCD at follow-up. There was a trend for family history of ED being predictive of ED diagnosis. Five (30%) of those who developed an ED at follow-up had ED symptoms or food-related obsessions/compulsions at baseline. A difference in predictors for an ED versus other anxiety disorders at follow-up was identified.
This study provides initial evidence that baseline clinical predictors such as female gender and family history of ED might be specific to the later development of ED in the context of childhood OCD. Clinicians should be alert to ED subthreshold symptoms in young girls presenting with OCD. Future longitudinal studies are needed to clarify the relationship between childhood OCD and later ED.
有人认为儿童强迫症 (OCD) 可能是日后发生饮食障碍 (ED) 的危险因素,但缺乏前瞻性研究。我们旨在确定在儿童期被诊断为 OCD 的青少年/年轻成人的纵向临床样本中,随访时 ED 的患病率和临床预测因子。
本研究纳入了在全国和专科儿科 OCD 诊所接受评估超过 9 年的所有可联系的 (n=231) OCD 年轻患者。在随访时,126 名 (57%) 年轻人及其父母完成了发展和健康评估的 ED 部分。使用逻辑回归调查 ED 的预测因子。
共有 16 名参与者 (12.7%) 在随访时被诊断为 ED。患有 ED 与女性性别和随访时持续存在的 OCD 有关。ED 家族史有预测 ED 诊断的趋势。在随访时出现 ED 的 5 名参与者 (30%) 在基线时有 ED 症状或与食物相关的强迫观念/强迫行为。确定了随访时 ED 与其他焦虑障碍的预测因子存在差异。
本研究初步证明了基线临床预测因子,如女性性别和 ED 家族史,可能与儿童 OCD 背景下 ED 的后期发展有关。临床医生应警惕患有 OCD 的年轻女孩出现 ED 亚阈值症状。需要未来的纵向研究来阐明儿童 OCD 和以后 ED 之间的关系。