Division of Life Style Studies, Section of Nutritional Sciences, Graduate School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka, Hikone, Shiga 522-8533, Japan.
Br J Nutr. 2012 Jan;107(1):52-60. doi: 10.1017/S0007114511002339. Epub 2011 Jun 27.
Prolonged starvation changes energy metabolism; therefore, the metabolic response to starvation is divided into three phases according to changes in glucose, lipid and protein utilisation. B-group vitamins are involved in energy metabolism via metabolism of carbohydrates, fatty acids and amino acids. To determine how changes in energy metabolism alter B-group vitamin concentrations during starvation, we measured the concentration of eight kinds of B-group vitamins daily in rat blood, urine and in nine tissues including cerebrum, heart, lung, stomach, kidney, liver, spleen, testis and skeletal muscle during 8 d of starvation. Vitamin B1, vitamin B6, pantothenic acid, folate and biotin concentrations in the blood reduced after 6 or 8 d of starvation, and other vitamins did not change. Urinary excretion was decreased during starvation for all B-group vitamins except pantothenic acid and biotin. Less variation in B-group vitamin concentrations was found in the cerebrum and spleen. Concentrations of vitamin B1, vitamin B6, nicotinamide and pantothenic acid increased in the liver. The skeletal muscle and stomach showed reduced concentrations of five vitamins including vitamin B1, vitamin B2, vitamin B6, pantothenic acid and folate. Concentrations of two or three vitamins decreased in the kidney, testis and heart, and these changes showed different patterns in each tissue and for each vitamin. The concentration of pantothenic acid rapidly decreased in the heart, stomach, kidney and testis, whereas concentrations of nicotinamide were stable in all tissues except the liver. Different variations in B-group vitamin concentrations in the tissues of starved rats were found. The present findings will lead to a suitable supplementation of vitamins for the prevention of the re-feeding syndrome.
长期饥饿会改变能量代谢；因此，根据葡萄糖、脂质和蛋白质利用的变化，将饥饿的代谢反应分为三个阶段。B 族维生素通过碳水化合物、脂肪酸和氨基酸的代谢参与能量代谢。为了确定能量代谢的变化如何改变饥饿期间 B 族维生素浓度，我们在 8 天的饥饿期间每天测量大鼠血液、尿液和包括大脑、心脏、肺、胃、肾脏、肝脏、脾脏、睾丸和骨骼肌在内的 9 种组织中的 8 种 B 族维生素的浓度。维生素 B1、维生素 B6、泛酸、叶酸和生物素的血液浓度在饥饿 6 或 8 天后降低，而其他维生素没有变化。除了泛酸和生物素外，所有 B 族维生素的尿排泄在饥饿期间都减少。大脑和脾脏中 B 族维生素浓度的变化较小。维生素 B1、维生素 B6、烟酰胺和泛酸在肝脏中的浓度增加。骨骼肌和胃显示出五种维生素（包括维生素 B1、维生素 B2、维生素 B6、泛酸和叶酸）的浓度降低。肾脏、睾丸和心脏中的两种或三种维生素浓度降低，这些变化在每种组织和每种维生素中表现出不同的模式。泛酸在心脏、胃、肾脏和睾丸中的浓度迅速下降，而除肝脏外，烟酰胺在所有组织中的浓度都稳定。在饥饿大鼠的组织中发现了 B 族维生素浓度的不同变化。这些发现将有助于为预防再喂养综合征选择合适的维生素补充剂。
