Shibata Katsumi, Hirose Junko, Fukuwatari Tsutomu
Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan.
Nutr Metab Insights. 2014 Aug 5;7:61-75. doi: 10.4137/NMI.S17245. eCollection 2014.
Excess water-soluble vitamins are thought to be eliminated in the urine. We have reported a strong relationship between water-soluble vitamin intake and urinary excretion in females. The relationship, however, is not well understood in males. In the present experiment, 10 Japanese male subjects were given a standard Japanese diet for the first week. The subjects remained on the same diet, and a synthesized water-soluble vitamin mixture containing one time the Dietary Reference Intakes (DRIs) for Japanese was given for the second week, three times the DRIs for the third week, and six times the DRIs for the fourth week. Twenty-four-hour urine samples were collected each week. Urinary excretion levels for seven of the nine water-soluble vitamin levels, excluding vitamin B12 and folate, increased linearly and sharply in a dose-dependent manner. These results suggest that measuring urinary water-soluble vitamins can be good nutritional markers for assessing vitamin intakes in humans.
过量的水溶性维生素被认为会通过尿液排出体外。我们已经报道了女性水溶性维生素摄入量与尿液排泄之间存在密切关系。然而，这种关系在男性中尚未得到充分了解。在本实验中，10名日本男性受试者在第一周食用标准日本饮食。受试者继续食用相同饮食，在第二周给予含日本膳食参考摄入量（DRIs）一倍量的合成水溶性维生素混合物，第三周给予三倍量的DRIs，第四周给予六倍量的DRIs。每周收集24小时尿液样本。除维生素B12和叶酸外，九种水溶性维生素中的七种的尿液排泄水平呈剂量依赖性线性急剧增加。这些结果表明，测量尿液中的水溶性维生素可以作为评估人体维生素摄入量的良好营养指标。
