二甲双胍联合口服避孕药治疗对超重和肥胖多囊卵巢综合征妇女代谢因素及血管内皮功能的影响。
Effect of combined metformin and oral contraceptive therapy on metabolic factors and endothelial function in overweight and obese women with polycystic ovary syndrome.
机构信息
Department of Internal Medicine, School of Medicine, Medical College of Virginia Hospitals, Virginia Commonwealth University, Richmond, Virginia, USA.
出版信息
Fertil Steril. 2011 Aug;96(2):501-504.e2. doi: 10.1016/j.fertnstert.2011.05.091. Epub 2011 Jul 5.
Abstract
In this randomized, double-blind, placebo-controlled study, 19 overweight women with polycystic ovary syndrome were randomized to a 3-month course of either metformin plus combined hormonal oral contraceptive (OC) (n = 9) or OC plus matched placebo (n = 10). After 3 months, both treatments had similar effects on androgen levels, lipid profile, insulin sensitivity, and serum inflammatory markers, but flow-mediated dilatation increased by 69.0% in the metformin plus OC group while it remained unchanged in the OC group. CLINICAL TRIAL REGISTRATION NO: NCT00682890.
摘要
在这项随机、双盲、安慰剂对照研究中，19 名患有多囊卵巢综合征的超重女性被随机分为三组，分别接受为期 3 个月的二甲双胍联合复方激素口服避孕药（OC）治疗（n = 9）、OC 联合匹配安慰剂治疗（n = 10）。3 个月后，两种治疗方法在雄激素水平、血脂谱、胰岛素敏感性和血清炎症标志物方面均有相似的效果，但二甲双胍联合 OC 组的血流介导扩张增加了 69.0%，而 OC 组则保持不变。临床试验注册号：NCT00682890。
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