肝脏胆钙化醇25-羟化酶将氧-18掺入胆钙化醇的25位。
Incorportion of oxygen-18 into the 25-position of cholecalciferol by hepatic cholecalciferol 25-hydroxylase.
作者信息
Madhok T C, Schnoes H K, DeLuca H F
出版信息
Biochem J. 1978 Nov 1;175(2):479-82. doi: 10.1042/bj1750479.
Abstract
The oxygen enzymically inserted as a hydroxy function by rat liver post-mitochondrial fraction into the 25-position of cholecalciferol to giver 25-hydroxycholecaliferol is derived exclusively from molecular O2. Therefore like the other two cholecalciferol hydroxylases, i.e. 25-hydroxycholecalciferol 1alpha-hydroxylase and 25-hydroxycholecalciferol 24-hydroxylase, the cholecalciferol 25-hydroxylase is also a mono-oxygenase ('mixed-function oxidase').
摘要
大鼠肝脏线粒体后成分通过酶促作用将氧作为羟基插入胆钙化醇的25位以生成25-羟胆钙化醇，该氧仅来源于分子氧。因此，与其他两种胆钙化醇羟化酶，即25-羟胆钙化醇1α-羟化酶和25-羟胆钙化醇24-羟化酶一样，胆钙化醇25-羟化酶也是一种单加氧酶（“混合功能氧化酶”）。
相似文献
1
Incorportion of oxygen-18 into the 25-position of cholecalciferol by hepatic cholecalciferol 25-hydroxylase.肝脏胆钙化醇25-羟化酶将氧-18掺入胆钙化醇的25位。
Biochem J. 1978 Nov 1;175(2):479-82. doi: 10.1042/bj1750479.
2
Characteristics of the rat liver microsomal enzyme system converting cholecalciferol into 25-hydroxycholecalciferol. Evidence for the participation of cytochrome p-450.将胆钙化醇转化为25-羟胆钙化醇的大鼠肝脏微粒体酶系统的特性。细胞色素P-450参与的证据。
Biochem J. 1979 Dec 15;184(3):491-9. doi: 10.1042/bj1840491.
3
Cholecalciferol 25-hydroxylation is similar in liver microsomes from male and female rats when cholecalciferol concentration is low.
J Nutr. 1995 Jan;125(1):104-11. doi: 10.1093/jn/125.1.104.
4
Kidney microsomal 25- and 1alpha-hydroxylase in vitamin D metabolism: catalytic properties, molecular cloning, cellular localization and expression during development.维生素D代谢中的肾脏微粒体25-羟化酶和1α-羟化酶：催化特性、分子克隆、细胞定位及发育过程中的表达
Biochim Biophys Acta. 2002 Feb 28;1580(2-3):133-44. doi: 10.1016/s1388-1981(01)00192-5.
5
Comparative studies on the 25-hydroxylations of cholecalciferol and 1 alpha-hydroxycholecalfierol in perfused rat liver.灌流大鼠肝脏中胆钙化醇和1α-羟基胆钙化醇25-羟化反应的比较研究
Biochem J. 1978 Mar 15;170(3):495-502. doi: 10.1042/bj1700495.
6
The metabolism of cholecalciferol in the liver of Japanese quail (Coturnix coturnix japonica) with particular reference to the effects of oestrogen.日本鹌鹑（Coturnix coturnix japonica）肝脏中胆钙化醇的代谢，特别提及雌激素的影响。
Biochem J. 1979 Sep 15;182(3):745-50. doi: 10.1042/bj1820745.
7
Sex differences in the hydroxylation of cholecalciferol and of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol in rat liver.大鼠肝脏中胆钙化醇和5β-胆甾烷-3α,7α,12α-三醇羟基化作用的性别差异。
Biochem J. 1987 Oct 1;247(1):73-8. doi: 10.1042/bj2470073.
8
Assay and properties of a mitochondrial 25-hydroxylase active on vitamine D3.对维生素D3有活性的线粒体25-羟化酶的测定及性质
J Biol Chem. 1978 Feb 10;253(3):842-9.
9
Calciferol 25-hydroxylase activity in smooth and rough endoplasmic reticulum of rat liver.大鼠肝脏滑面和粗面内质网中维生素D25-羟化酶的活性
Arch Biochem Biophys. 1979 Jun;195(1):45-52. doi: 10.1016/0003-9861(79)90325-4.
10
The involvement of intracellular calcium ion concentration and calmodulin in the 25-hydroxylation of cholecalciferol in ovine and rat liver.细胞内钙离子浓度和钙调蛋白在绵羊和大鼠肝脏中胆钙化醇25-羟化过程中的作用。
Cell Calcium. 1987 Aug;8(4):247-58. doi: 10.1016/0143-4160(87)90001-7.
引用本文的文献
1
Reduction of circulating 25-hydroxyvitamin D by antipyrine.安替比林降低循环中的25-羟基维生素D水平。
Br J Clin Pharmacol. 1979 Dec;8(6):523-8. doi: 10.1111/j.1365-2125.1979.tb01039.x.
2
Characteristics of the rat liver microsomal enzyme system converting cholecalciferol into 25-hydroxycholecalciferol. Evidence for the participation of cytochrome p-450.将胆钙化醇转化为25-羟胆钙化醇的大鼠肝脏微粒体酶系统的特性。细胞色素P-450参与的证据。
Biochem J. 1979 Dec 15;184(3):491-9. doi: 10.1042/bj1840491.
本文引用的文献
1
Mechanism of 25-hydroxycholecalciferol 1 -hydroxylation. Incorporation of oxygen-18 into the 1 position of 25-hydroxycholecalciferol.25-羟基胆钙化醇1-羟化的机制。氧-18掺入25-羟基胆钙化醇的1位。
Biochemistry. 1973 Jul 3;12(14):2555-8. doi: 10.1021/bi00738a001.
2
Vitamin D: the vitamin and the hormone.维生素D：维生素与激素
Fed Proc. 1974 Nov;33(11):2211-9.
3
Subcellular location of rat liver calciferol-25-hydroxylase.大鼠肝脏维生素D3-25-羟化酶的亚细胞定位。
Arch Biochem Biophys. 1974 Jan;160(1):58-62. doi: 10.1016/s0003-9861(74)80008-1.
4
5
Vitamin D 3 -25-hydroxylase: tissue occurrence and apparent lack of regulation.维生素D 3-25-羟化酶：组织分布及明显缺乏调控
Arch Biochem Biophys. 1973 Mar;155(1):47-57. doi: 10.1016/s0003-9861(73)80008-6.
6
"Activation" of vitamin D by the liver.肝脏对维生素D的“激活”。
J Clin Invest. 1969 Nov;48(11):2032-7. doi: 10.1172/JCI106168.
7
In vitro production of 25-hydroxycholecalciferol.25-羟基胆钙化醇的体外生产。
Biochem Biophys Res Commun. 1969 Jul 23;36(2):251-6. doi: 10.1016/0006-291x(69)90322-2.
8
25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3.
Biochemistry. 1968 Oct;7(10):3317-22. doi: 10.1021/bi00850a001.
9
Mitochondrial cytochrome p450. A component of chick kidney 25-hydrocholecalciferol-1alpha-hydroxylase.线粒体细胞色素P450。鸡肾25-羟胆钙化醇-1α-羟化酶的一个组分。
J Biol Chem. 1974 May 25;249(10):3026-33.
10
25-Hydroxycholecalciferol-1-hydroxylase: a specific requirement for NADPH and a hemoprotein component in chick kidney mitochondria.
Arch Biochem Biophys. 1974 Jan;160(1):63-72. doi: 10.1016/s0003-9861(74)80009-3.
Zotero 插件