Ponchon G, Kennan A L, DeLuca H F
J Clin Invest. 1969 Nov;48(11):2032-7. doi: 10.1172/JCI106168.
Isolation of the liver from the circulation of rats eliminates almost completely their ability to convert [1,2]-(3)H vitamin D(3) into its biologically active metabolite, 25-hydroxycholecalciferol, as well as certain other metabolites. It is concluded that the liver is the major if not the only physiologic site of hydroxylation of vitamin D(3) (cholecalciferol) into 25-hydroxycholecalciferol. The osteodystrophy and the higher requirements for vitamin D observed in hepatic insufficiencies may be due to an inability of the liver to transform vitamin D into its metabolically active form.
将大鼠肝脏与循环系统隔离,几乎完全消除了它们将[1,2]-(3)H维生素D3转化为其生物活性代谢物25-羟胆钙化醇以及某些其他代谢物的能力。得出的结论是,肝脏即使不是维生素D3(胆钙化醇)羟化生成25-羟胆钙化醇的唯一生理部位,也是主要部位。在肝功能不全时观察到的骨营养不良和对维生素D的更高需求,可能是由于肝脏无法将维生素D转化为其代谢活性形式。