Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.
Nephron Exp Nephrol. 2011;119(2):e33-9. doi: 10.1159/000327589. Epub 2011 Jul 7.
BACKGROUND/AIMS: The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in the treatment of immunoglobulin A nephropathy (IgAN) have been reported. Perilla frutescens (Linn.) Britton var. frutescens is grown in Eastern Asia and its seed (perilla seed) is rich in α-linolenic acid, an n-3 PUFA. We investigated the antinephritic effects of perilla seed oil in a mouse model of IgAN.
Ten-week-old high IgA ddY mice were fed diets containing either perilla seed oil (PS group) or corn oil (C group, control). After 20 weeks, we compared body weight, blood pressure, serum creatinine levels, IgA levels, fatty acid composition, urinary protein excretion, mesangial matrix expansion, and glomerular transforming growth factor-β1 mRNA expression between groups.
Serum n-3 PUFA levels were higher in the PS group than the C group (p<0.001). Blood urea nitrogen levels were lower (p=0.0246) and urinary protein excretion was reduced (p=0.0198) in the PS group. Mesangial matrix expansion (p=0.0063) and glomerular transforming growth factor-β1 mRNA expression (p=0.0291) were suppressed in the PS group. No significant differences between groups were found in body weight, blood pressure, serum IgA, and creatinine levels.
Dietary perilla seed oil supplement could suppress the progression of IgAN.
背景/目的：已经有报道称ω-3 多不饱和脂肪酸（n-3 PUFA）对治疗免疫球蛋白 A 肾病（IgAN）有益。荏（Perilla frutescens （Linn.） Britton var. frutescens）生长在东亚，其种子（紫苏籽）富含α-亚麻酸，这是一种 n-3 PUFA。我们研究了紫苏籽油对 IgAN 小鼠模型的抗肾炎作用。
10 周龄高 IgA ddY 小鼠分别喂食含紫苏籽油（PS 组）或玉米油（C 组，对照组）的饮食。20 周后，我们比较了各组间的体重、血压、血清肌酐水平、IgA 水平、脂肪酸组成、尿蛋白排泄量、系膜基质扩张和肾小球转化生长因子-β1 mRNA 表达。
PS 组血清 n-3 PUFA 水平高于 C 组（p<0.001）。PS 组的血尿素氮水平较低（p=0.0246），尿蛋白排泄量减少（p=0.0198）。PS 组系膜基质扩张（p=0.0063）和肾小球转化生长因子-β1 mRNA 表达（p=0.0291）受到抑制。两组间的体重、血压、血清 IgA 和肌酐水平无显著差异。
饮食补充紫苏籽油可抑制 IgAN 的进展。
