• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

提取物对IgA肾病的影响：一项系统评价与Meta分析

The Effects of Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis.

作者信息

Adam Gigi, Adam Ana-Maria, Robu Silvia, Harabor Valeriu, Harabor Anamaria, Nechita Aurel, Marin Denisa Batir, Morariu Ionela-Daniela, Cioanca Oana, Vasilache Ingrid-Andrada, Hancianu Monica

机构信息

Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.

Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800216 Galati, Romania.

出版信息

Pharmaceuticals (Basel). 2023 Jul 10;16(7):988. doi: 10.3390/ph16070988.

DOI:10.3390/ph16070988
PMID:37513901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10385934/
Abstract

(1) Background: Chronic renal disorders (CRD) are associated with significant comorbidities and necessitate complex therapeutic management. As time passed, (PF) became a promising therapeutic option for CRD. The aim of this systematic review and meta-analysis was to outline the therapeutic effects of PF extracts on various models of immunoglobulin a (IgA) nephropathy; (2) Methods: Medline, Embase, and Cochrane databases were used to find relevant studies. All prospective interventional studies that evaluated the effect of PF extract versus placebo on rat models of chronic renal disorders were assessed according to the international guidelines; (3) Results: Our search yielded 23 unique records, out of which only five were included in the analysis. Our results showed that administration of PF extracts led to a statistically significant reduction in proteinuria and PCNA levels in rats that received high doses of the extract as well as in the PCNA level and DNA synthesis in rats that received low doses of the extract. The evaluated outcomes benefited from a low degree of heterogeneity; (4) Conclusions: Some of the evaluated outcomes were significantly reduced by both high and low doses of extracts from . Further studies are needed to determine the exact effect over IgA nephropathy in human subjects.

摘要

(1) 背景：慢性肾脏疾病（CRD）与多种严重合并症相关，需要复杂的治疗管理。随着时间推移，（PF）成为CRD一种有前景的治疗选择。本系统评价和荟萃分析的目的是概述PF提取物对各种免疫球蛋白A（IgA）肾病模型的治疗效果；(2) 方法：使用Medline、Embase和Cochrane数据库查找相关研究。所有评估PF提取物与安慰剂对慢性肾脏疾病大鼠模型影响的前瞻性干预研究均按照国际指南进行评估；(3) 结果：我们的检索产生了23条独特记录，其中仅5条纳入分析。我们的结果表明，给予PF提取物导致接受高剂量提取物的大鼠蛋白尿和增殖细胞核抗原（PCNA）水平以及接受低剂量提取物的大鼠PCNA水平和DNA合成在统计学上显著降低。评估结果的异质性程度较低；(4) 结论：高剂量和低剂量的提取物均使某些评估结果显著降低。需要进一步研究以确定对人类IgA肾病的确切影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/228dab9f3152/pharmaceuticals-16-00988-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/167a2d10338b/pharmaceuticals-16-00988-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/02362abd9648/pharmaceuticals-16-00988-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/f2065ea429d1/pharmaceuticals-16-00988-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/da3022bd09ce/pharmaceuticals-16-00988-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/23c0675fafce/pharmaceuticals-16-00988-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/17f2df354d99/pharmaceuticals-16-00988-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/c2298a3bbbe4/pharmaceuticals-16-00988-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/fa1e6a56a4e5/pharmaceuticals-16-00988-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/228dab9f3152/pharmaceuticals-16-00988-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/167a2d10338b/pharmaceuticals-16-00988-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/02362abd9648/pharmaceuticals-16-00988-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/f2065ea429d1/pharmaceuticals-16-00988-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/da3022bd09ce/pharmaceuticals-16-00988-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/23c0675fafce/pharmaceuticals-16-00988-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/17f2df354d99/pharmaceuticals-16-00988-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/c2298a3bbbe4/pharmaceuticals-16-00988-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/fa1e6a56a4e5/pharmaceuticals-16-00988-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f7/10385934/228dab9f3152/pharmaceuticals-16-00988-g009.jpg

相似文献

1
The Effects of Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis.提取物对IgA肾病的影响：一项系统评价与Meta分析
Pharmaceuticals (Basel). 2023 Jul 10;16(7):988. doi: 10.3390/ph16070988.
2
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区，服用抗叶酸抗疟药物的人群中，叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
3
Applications of Extracts in Clinical Practice.提取物在临床实践中的应用。
Antioxidants (Basel). 2023 Mar 16;12(3):727. doi: 10.3390/antiox12030727.
4
Suppressive effects of Perilla frutescens on spontaneous IgA nephropathy in ddY mice.紫苏对ddY小鼠自发性IgA肾病的抑制作用。
Nephron. 1999 Sep;83(1):40-6. doi: 10.1159/000045471.
5
Suppressive effects of Perilla frutescens on IgA nephropathy in HIGA mice.紫苏对HIGA小鼠IgA肾病的抑制作用。
Nephrol Dial Transplant. 2003 Mar;18(3):484-90. doi: 10.1093/ndt/18.3.484.
6
Phytosynthesis of Silver Nanoparticles Using Leaf Extract: Characterization and Evaluation of Antibacterial, Antioxidant, and Anticancer Activities.利用叶提取物合成银纳米粒子：抗菌、抗氧化和抗癌活性的表征和评价。
Int J Nanomedicine. 2021 Jan 6;16:15-29. doi: 10.2147/IJN.S265003. eCollection 2021.
7
Assessing the Antioxidant Properties, In Vitro Cytotoxicity and Antitumoral Effects of Polyphenol-Rich Extracts.评估富含多酚提取物的抗氧化特性、体外细胞毒性和抗肿瘤作用。
Antioxidants (Basel). 2023 Dec 29;13(1):58. doi: 10.3390/antiox13010058.
8
Suppressive effects of Perilla frutescens on mesangioproliferative glomerulonephritis in rats.紫苏对大鼠系膜增生性肾小球肾炎的抑制作用。
Biol Pharm Bull. 2001 Feb;24(2):172-5. doi: 10.1248/bpb.24.172.
9
Immunosuppressive agents for treating IgA nephropathy.用于治疗IgA肾病的免疫抑制剂。
Cochrane Database Syst Rev. 2020 Mar 12;3(3):CD003965. doi: 10.1002/14651858.CD003965.pub3.
10
Perilla extract improves gastrointestinal discomfort in a randomized placebo controlled double blind human pilot study.在一项随机、安慰剂对照、双盲人体初步研究中，紫苏提取物可改善胃肠道不适。
BMC Complement Altern Med. 2014 May 27;14:173. doi: 10.1186/1472-6882-14-173.

引用本文的文献

1
Assessing the Antioxidant Properties, In Vitro Cytotoxicity and Antitumoral Effects of Polyphenol-Rich Extracts.评估富含多酚提取物的抗氧化特性、体外细胞毒性和抗肿瘤作用。
Antioxidants (Basel). 2023 Dec 29;13(1):58. doi: 10.3390/antiox13010058.

本文引用的文献

1
Applications of Extracts in Clinical Practice.提取物在临床实践中的应用。
Antioxidants (Basel). 2023 Mar 16;12(3):727. doi: 10.3390/antiox12030727.
2
Crescents and IgA Nephropathy: A Delicate Marriage.新月体与IgA肾病：一段微妙的关系
J Clin Med. 2022 Jun 21;11(13):3569. doi: 10.3390/jcm11133569.
3
seed oil combined with leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: a possible supplement for brain health.种子油联合叶粉通过降低健康老年日本个体的血清甘油三酯和葡萄糖水平来减轻与年龄相关的认知能力下降：一种可能的大脑健康补充剂。
Food Funct. 2022 Jul 4;13(13):7226-7239. doi: 10.1039/d2fo00723a.
4
Genome-Wide Analysis of the Fatty Acid Desaturase Gene Family Reveals the Key Role of in α-Linolenic Acid Biosynthesis in Perilla Seeds.脂肪酸去饱和酶基因家族的全基因组分析揭示了其在紫苏种子α-亚麻酸生物合成中的关键作用。
Front Genet. 2021 Nov 24;12:735862. doi: 10.3389/fgene.2021.735862. eCollection 2021.
5
Current treatment of IgA nephropathy.IgA 肾病的治疗现状。
Semin Immunopathol. 2021 Oct;43(5):717-728. doi: 10.1007/s00281-021-00888-3. Epub 2021 Sep 8.
6
Effects of Dietary n-3 and n-6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis.膳食 n-3 和 n-6 多不饱和脂肪酸在炎症和癌症发生中的作用。
Int J Mol Sci. 2021 Jun 28;22(13):6965. doi: 10.3390/ijms22136965.
7
IgA Nephropathy: An Interesting Autoimmune Kidney Disease.IgA 肾病：一种有趣的自身免疫性肾脏疾病。
Am J Med Sci. 2021 Feb;361(2):176-194. doi: 10.1016/j.amjms.2020.10.003. Epub 2020 Oct 8.
8
Quantifying Cell Proliferation During Regeneration of Aquatic Worms.量化水生环节动物再生过程中的细胞增殖。
Methods Mol Biol. 2021;2219:163-180. doi: 10.1007/978-1-0716-0974-3_10.
9
IgA nephropathy: A brief review.IgA 肾病：简要综述。
Semin Diagn Pathol. 2020 May;37(3):143-147. doi: 10.1053/j.semdp.2020.03.001. Epub 2020 Mar 16.
10
A Global Evolutionary Trend of the Frequency of Primary Glomerulonephritis over the Past Four Decades.过去四十年来原发性肾小球肾炎发病率的全球演变趋势。
Kidney Dis (Basel). 2019 Oct;5(4):247-258. doi: 10.1159/000500142. Epub 2019 Jun 11.