Department of Pediatrics, Loma Linda University, 11175 Campus Street, Coleman Pavilion A1121, Loma Linda, CA 92350, USA.
World J Gastroenterol. 2011 Jun 21;17(23):2791-800. doi: 10.3748/wjg.v17.i23.2791.
Irritable bowel syndrome (IBS) is defined by the Rome III criteria as symptoms of recurrent abdominal pain or discomfort with the onset of a marked change in bowel habits with no evidence of an inflammatory, anatomic, metabolic, or neoplastic process. As such, many clinicians regard IBS as a central nervous system problem of altered pain perception. Here, we review the recent literature and discuss the evidence that supports an organic based model, which views IBS as a complex, heterogeneous, inter-dependent, and multi-variable inflammatory process along the neuronal-gut axis. We delineate the organic pathophysiology of IBS, demonstrate the role of inflammation in IBS, review the possible differences between adult and pediatric IBS, discuss the merits of a comprehensive treatment model as taught by the Institute of Functional Medicine, and describe the potential for future research for this syndrome.
肠易激综合征（IBS）根据罗马 III 标准定义为反复发作的腹痛或不适，伴有明显的排便习惯改变，无炎症、解剖、代谢或肿瘤过程的证据。因此，许多临床医生将 IBS 视为改变疼痛感知的中枢神经系统问题。在这里，我们回顾了最近的文献，并讨论了支持基于有机模型的证据，该模型将 IBS 视为沿神经元-肠道轴的复杂、异质、相互依存和多变量炎症过程。我们描述了 IBS 的有机病理生理学，展示了炎症在 IBS 中的作用，回顾了成人和儿童 IBS 之间可能存在的差异，讨论了功能医学研究所教授的综合治疗模式的优点，并描述了该综合征未来研究的潜力。
