Departamento de Genética, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Genet Mol Biol. 2011 Apr;34(2):205-7. doi: 10.1590/s1415-47572011000200006. Epub 2011 Apr 1.
Ghrelin coded by the GHRL gene is related to weight-gain, its deactivation possibly depending on its hydrolyzation by butyrylcholinesterase (BChE) encoded by the BCHE gene, an enzyme already associated with the body mass index (BMI). The aim was to search for relationships between SNPs of the GHRL and BCHE genes with BChE activity, BMI and obesity in 144 obese and 153 nonobese Euro-Brazilian male blood donors. In the obese individuals, a significant association with higher BChE activity, in the 72LM+72MM; -116GG genotype class (GHRL and BCHE genes, respectively) was noted. No significant differences were found otherwise, through comparisons between obese and control individuals, of genotype and allele frequencies in SNPs of the GHRL gene (Arg51Gln and Leu72Met), or mean BMI between 72LL and 72LM+72MM genotypes. Although there appears to be no direct relationship between the examined GHRL SNPs and BMI, the association of the 72M SNP with higher BChE activity in obese subjects probably points to a regulatory mechanism, thereby implying the influence of the GHRL gene on BChE expression, and a consequential metabolic role in the complex process of fat utilization.
胃饥饿素由 GHRL 基因编码，与体重增加有关，其失活可能取决于由 BCHE 基因编码的丁酰胆碱酯酶（BChE）的水解，BChE 酶已与体重指数（BMI）相关联。本研究旨在探讨 GHRL 和 BCHE 基因的 SNP 与肥胖个体中 BChE 活性、BMI 和肥胖之间的关系，共纳入了 144 名肥胖和 153 名非肥胖的欧洲-巴西男性献血者。在肥胖个体中，发现 GHRL 和 BCHE 基因分别为 72LM+72MM 和-116GG 基因型时，BChE 活性显著升高。未发现 GHRL 基因的 Arg51Gln 和 Leu72Met 位点 SNP 以及 72LL 和 72LM+72MM 基因型之间 BMI 的均值存在组间差异。虽然研究中未发现 GHRL SNP 与 BMI 之间存在直接关系，但在肥胖个体中，72M SNP 与更高的 BChE 活性相关，这可能提示存在一种调节机制，即 GHRL 基因对 BChE 表达的影响，以及在脂肪利用的复杂过程中具有代谢作用。
