Wang Song Ling, Gao Run Tao
Salivary Gland Disease Center and Molecular Laboratory for Gene Therapy and Tooth Regeneration, Capital Medical University School of Stomatology, Beijing, PR China.
Chin J Dent Res. 2011;14(1):7-13.
Radiation therapy for malignant tumours in the head and neck region are inevitably associated with significant long-term injury to the salivary glands, often resulting in salivary gland hypofunction. The subsequent lack of saliva production leads to many functional and quality-of-life problems for affected patients and there is no effective method to eliminating this problem caused by radiation treatments. Although many studies have been done in animal models, the mechanism of this injury in humans is still unclear. In this review, an animal model (miniature pigs) used in irradiated research is mainly discussed. This review also presents the progress made to date on the gene transfer-mediated functional restoration of irradiated salivary glands and the possibilities provided by future interventions to prevent radiation damage to salivary glands.
头颈部恶性肿瘤的放射治疗不可避免地会对唾液腺造成严重的长期损伤，常常导致唾液腺功能减退。随后唾液分泌不足给受影响的患者带来许多功能和生活质量问题，并且没有有效的方法来消除这种由放射治疗引起的问题。尽管在动物模型方面已经开展了许多研究，但人类唾液腺损伤的机制仍不清楚。在这篇综述中，主要讨论了用于辐射研究的动物模型（小型猪）。本综述还介绍了迄今为止在基因转移介导的受辐射唾液腺功能恢复方面取得的进展，以及未来干预措施预防唾液腺辐射损伤的可能性。
