Tridon A, Albuisson E, Deteix P, Marquès Verdier A, Gaillard G, Bétail G, Baguet J C
Laboratoire d'Immunologie, Faculté Médecine Pharmacie, Clermont-Ferrand, France.
Artif Organs. 1990 Oct;14(5):387-90. doi: 10.1111/j.1525-1594.1990.tb02986.x.
Leukotrienes are eicosanoids arising from arachidonic acid via 5 lipooxygenase, an enzyme essentially present in leukocyte cells. Leukotriene B4 might be an indicator of neutropolymorphonuclear leukocyte activation when there is contact with artificial membranes. The level of plasmatic leukotriene B4 was measured at three different times during the hemodialysis treatment in several patients undergoing dialysis on three different membranes (one cellulosic and two synthetics). A moderate increase of leukotriene B4 was observed early (at 15 min), comparable among the three membranes, but levels returned to baseline at 180 min. Leukotriene B4 production proved leukocyte activation and was probably related to a direct interaction with dialysis membrane. Nevertheless, complement intervention could not be excluded. Leukotriene B4 is one molecule more among the group of inflammatory mediators produced during hemodialysis treatment.
白三烯是通过5-脂氧合酶由花生四烯酸产生的类二十烷酸，该酶主要存在于白细胞中。当与人工膜接触时，白三烯B4可能是中性多形核白细胞活化的一个指标。在接受三种不同膜（一种纤维素膜和两种合成膜）透析的几名患者的血液透析治疗过程中的三个不同时间点测量了血浆白三烯B4的水平。早期（15分钟时）观察到白三烯B4有适度增加，三种膜之间相当，但在180分钟时水平恢复到基线。白三烯B4的产生证明了白细胞的活化，并且可能与与透析膜的直接相互作用有关。然而，不能排除补体的干预。白三烯B4是血液透析治疗过程中产生的一组炎症介质中的又一个分子。
