Dumville Jo C, Walter Catherine J, Sharp Catherine A, Page Tamara
Department of Health Sciences, University of York, York, UK, YO10 5DD.
Cochrane Database Syst Rev. 2011 Jul 6(7):CD003091. doi: 10.1002/14651858.CD003091.pub2.
Surgical wounds (incisions) heal by primary intention when the wound edges are brought together and secured - often with sutures, staples, clips or glue. Wound dressings, usually applied after wound closure, provide physical support, protection from bacterial contamination and absorb exudate. Surgical site infection (SSI) is a common complication of surgical wounds that may delay healing.
To evaluate the effects of wound dressings for preventing SSI in people with surgical wounds healing by primary intention.
We searched the Cochrane Wounds Group Specialised Register (searched 10 May 2011); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011 Issue 2); Ovid MEDLINE (1950 to April Week 4 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, May 9, 2011); Ovid EMBASE (1980 to 2011 Week 18); EBSCO CINAHL (1982 to 6 May 2011). There were no restrictions based on language or date of publication.
Randomised controlled trials (RCTs) comparing alternative wound dressings or wound dressings with leaving wounds exposed for postoperative management of surgical wounds healing by primary intention.
Two review authors performed study selection, risk of bias assessment and data extraction independently.
Sixteen RCTs were included (2578 participants). All trials were at unclear or high risk of bias. Nine trials included people with wounds resulting from surgical procedures with a contamination classification of 'clean', two trials included people with wounds resulting from surgical procedures with a 'clean/contaminated' contamination classification and the remaining trials evaluated people with wounds resulting from various surgical procedures with different contamination classifications. Two trials compared wound dressings with leaving wounds exposed. The remaining 14 trials compared two alternative dressing types. No evidence was identified to suggest that any dressing significantly reduced the risk of developing an SSI compared with leaving wounds exposed or compared with alternative dressings in people who had surgical wounds healing by secondary intention.
AUTHORS' CONCLUSIONS: At present, there is no evidence to suggest that covering surgical wounds healing by primary intention with wound dressings reduces the risk of SSI or that any particular wound dressing is more effective than others in reducing the rates of SSI, improving scarring, pain control, patient acceptability or ease of dressing removal. Most trials in this review were small and of poor quality at high or unclear risk of bias. However, based on the current evidence, we conclude that decisions on wound dressing should be based on dressing costs and the symptom management properties offered by each dressing type e.g. exudate management.
当伤口边缘对合并固定(通常使用缝线、吻合钉、夹子或胶水)时,手术伤口(切口)通过一期愈合。伤口敷料通常在伤口闭合后应用,提供物理支撑、防止细菌污染并吸收渗出液。手术部位感染(SSI)是手术伤口常见的并发症,可能会延迟愈合。
评估伤口敷料对一期愈合的手术伤口患者预防SSI的效果。
我们检索了Cochrane伤口小组专门注册库(检索日期为2011年5月10日);Cochrane对照试验中心注册库(CENTRAL)(《Cochrane图书馆》2011年第2期);Ovid MEDLINE(1950年至2011年4月第4周);Ovid MEDLINE(在研及其他未索引的引用文献,2011年5月9日);Ovid EMBASE(1980年至2011年第18周);EBSCO CINAHL(1982年至2011年5月6日)。没有基于语言或出版日期的限制。
比较替代伤口敷料或伤口敷料与让伤口暴露进行一期愈合的手术伤口术后处理的随机对照试验(RCT)。
两位综述作者独立进行研究选择、偏倚风险评估和数据提取。
纳入了16项RCT(2578名参与者)。所有试验的偏倚风险均不明确或较高。9项试验纳入了污染分类为“清洁”的手术伤口患者,2项试验纳入了污染分类为“清洁/污染”的手术伤口患者,其余试验评估了污染分类不同的各种手术伤口患者。2项试验比较了伤口敷料与让伤口暴露的情况。其余14项试验比较了两种替代敷料类型。没有证据表明与让伤口暴露相比,或与二期愈合的手术伤口患者使用替代敷料相比,任何敷料能显著降低发生SSI的风险。
目前,没有证据表明用伤口敷料覆盖一期愈合的手术伤口可降低SSI风险,也没有证据表明任何特定的伤口敷料在降低SSI发生率、改善瘢痕形成、控制疼痛、患者可接受性或敷料去除的难易程度方面比其他敷料更有效。本综述中的大多数试验规模较小,质量较差,偏倚风险较高或不明确。然而,基于目前的证据,我们得出结论,伤口敷料的决策应基于敷料成本以及每种敷料类型提供的症状管理特性,如渗出液管理。