Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.
Molecules. 2020 Jun 10;25(11):2699. doi: 10.3390/molecules25112699.
As wound healing continues to be a challenge for the medical field, wound management has become an essential factor for healthcare systems. Nanotechnology is a domain that could provide different new approaches concerning regenerative medicine. It is worth mentioning the importance of nanoparticles, which, when embedded in biomaterials, can induce specific properties that make them of interest in applications as materials for wound dressings. In the last years, nano research has taken steps to develop molecular engineering strategies for different self-assembling biocompatible nanoparticles. It is well-known that nanomaterials can improve burn treatment and also the delayed wound healing process. In this review, the first-line of bioactive nanomaterials-based dressing categories frequently applied in clinical practice, including semi-permeable films, semipermeable foam dressings, hydrogel dressings, hydrocolloid dressings, alginate dressings, non-adherent contact layer dressings, and multilayer dressings will be discussed. Additionally, this review will highlight the lack of high-quality evidence and the necessity for future advanced trials because current wound healing therapies generally fail to provide an excellent clinical outcome, either structurally or functionally. The use of nanomaterials in wound management represents a unique tool that can be specifically designed to closely reflect the underlying physiological processes in tissue repair.
随着伤口愈合仍然是医学领域的一个挑战，伤口管理已成为医疗保健系统的一个重要因素。纳米技术是一个可以提供有关再生医学的不同新方法的领域。值得一提的是纳米粒子的重要性，将其嵌入生物材料中，可以诱导出使它们在用作伤口敷料材料的应用中具有吸引力的特定性质。在过去的几年中，纳米研究已经采取措施来开发用于不同自组装生物相容性纳米粒子的分子工程策略。众所周知，纳米材料可以改善烧伤治疗和延迟的伤口愈合过程。在这篇综述中，将讨论经常在临床实践中应用的基于生物活性纳米材料的第一类敷料类别，包括半透膜、半透泡沫敷料、水凝胶敷料、水胶体敷料、藻酸盐敷料、非粘连性接触层敷料和多层敷料。此外，本综述将强调缺乏高质量证据以及未来进行高级试验的必要性，因为目前的伤口愈合疗法在结构或功能上通常无法提供出色的临床效果。纳米材料在伤口管理中的应用代表了一种独特的工具，可以专门设计来紧密反映组织修复中的潜在生理过程。
