Department of Biomolecular Chemistry, Nijmegen Centre for Molecular Life Sciences, Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, The Netherlands.
Bioessays. 2011 Sep;33(9):674-82. doi: 10.1002/bies.201100048. Epub 2011 Jul 7.
Here we discuss the hypothesis that the RNA components of the Ro ribonucleoproteins (RNPs), the Y RNAs, can be processed into microRNAs (miRNAs). Although Ro RNPs, whose main protein components Ro60 and La are targeted by the immune system in several autoimmune diseases, were discovered many years ago, their function is still poorly understood. Indeed, recent data show that miRNA-sized small RNAs can be generated from Y RNAs. This hypothesis leads also to a model in which Ro60 acts as a modulator in the Y RNA-derived miRNA biogenesis pathway. The implications of these Y RNA-derived miRNAs, which may be specifically produced under pathological circumstances such as in autoimmunity or during viral infections, for the enigmatic function of Ro RNPs are discussed.
在这里，我们讨论了这样一种假设，即 Ro 核蛋白（RNP）的 RNA 成分，即 Y 小核仁 RNA，可以被加工成 microRNA（miRNA）。尽管 Ro RNP 的主要蛋白成分 Ro60 和 La 是几种自身免疫性疾病中免疫系统的靶向目标，但它们的功能仍知之甚少。事实上，最近的数据表明，miRNA 大小的小 RNA 可以从 Y RNA 中产生。这一假设还提出了一种模型，即 Ro60 作为 Y RNA 衍生 miRNA 生物发生途径中的调节剂。这些 Y RNA 衍生的 miRNA 可能是在自身免疫或病毒感染等病理情况下特异性产生的，对于 Ro RNP 神秘功能的影响正在讨论中。
