• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Autoimmunity: Ro60-associated RNA takes its toll on disease pathogenesis.

作者信息

Reed Joanne H, Gordon Tom P

机构信息

Garvan Institute of Medical Research, Immunology Division, Immunogenomics Laboratory, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.

Flinders Medical Centre and SA Pathology, Department of Immunology, Bedford Drive, Bedford Park, SA 5042, Australia.

出版信息

Nat Rev Rheumatol. 2016 Mar;12(3):136-8. doi: 10.1038/nrrheum.2015.148. Epub 2015 Nov 10.

DOI:10.1038/nrrheum.2015.148
PMID:26553602
Abstract
摘要

相似文献

1
Autoimmunity: Ro60-associated RNA takes its toll on disease pathogenesis.自身免疫：Ro60相关RNA对疾病发病机制产生影响。
Nat Rev Rheumatol. 2016 Mar;12(3):136-8. doi: 10.1038/nrrheum.2015.148. Epub 2015 Nov 10.
2
The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.Ro60自身抗原结合内源性逆转录元件并调节炎症基因表达。
Science. 2015 Oct 23;350(6259):455-9. doi: 10.1126/science.aac7442. Epub 2015 Sep 17.
3
Are the Ro RNP-associated Y RNAs concealing microRNAs? Y RNA-derived miRNAs may be involved in autoimmunity.Ro RNP 相关的 Y RNAs 是否隐藏了 microRNAs？Y RNA 衍生的 microRNAs 可能与自身免疫有关。
Bioessays. 2011 Sep;33(9):674-82. doi: 10.1002/bies.201100048. Epub 2011 Jul 7.
4
Y RNA derived small RNAs in Sjögren's syndrome: Candidate biomarkers?干燥综合征中的 Y RNA 衍生的小 RNA：候选生物标志物？
Int J Rheum Dis. 2017 Nov;20(11):1763-1766. doi: 10.1111/1756-185X.13229. Epub 2017 Nov 19.
5
Cellular microRNAs (miRNAs) and Sjögren's syndrome: candidate regulators of autoimmune response and autoantigen expression.细胞 microRNAs (miRNAs) 和干燥综合征：自身免疫反应和自身抗原表达的候选调节因子。
J Autoimmun. 2011 Sep;37(2):129-35. doi: 10.1016/j.jaut.2011.05.003. Epub 2011 May 31.
6
Subcellular redistribution and surface exposure of the Ro52, Ro60 and La48 autoantigens during apoptosis in human ductal epithelial cells: a possible mechanism in the pathogenesis of Sjögren's syndrome.人导管上皮细胞凋亡过程中Ro52、Ro60和La48自身抗原的亚细胞重新分布及表面暴露：干燥综合征发病机制中的一种可能机制。
Scand J Immunol. 2002 Nov;56(5):456-69. doi: 10.1046/j.1365-3083.2002.01072_79.x.
7
HLA and genetic predisposition to lupus erythematosus and other dermatologic disorders.人类白细胞抗原与红斑狼疮及其他皮肤病的遗传易感性
J Am Acad Dermatol. 1985 Sep;13(3):472-81. doi: 10.1016/s0190-9622(85)70191-0.
8
Alu retroelement-associated autoimmunity in Sjögren's syndrome.干燥综合征中与Alu逆转录元件相关的自身免疫
Oral Dis. 2016 Jul;22(5):345-7. doi: 10.1111/odi.12462. Epub 2016 Mar 10.
9
Humoral immunity to Ro52 is not associated with the Ro52 9571 C/T polymorphism in Australian patients with primary Sjögren's syndrome.在澳大利亚原发性干燥综合征患者中，针对Ro52的体液免疫与Ro52 9571 C/T基因多态性无关。
Arthritis Rheum. 2003 Nov;48(11):3293-4. doi: 10.1002/art.11309.
10
The functional role of complement genes in systemic lupus erythematosus and Sjögren's syndrome.补体基因在系统性红斑狼疮和干燥综合征中的功能作用。
Curr Opin Rheumatol. 1989 Oct;1(3):347-52. doi: 10.1097/00002281-198901030-00018.

引用本文的文献

1
Autoimmune diseases: targets, biology, and drug discovery.自身免疫性疾病：靶点、生物学和药物发现。
Acta Pharmacol Sin. 2024 Apr;45(4):674-685. doi: 10.1038/s41401-023-01207-2. Epub 2023 Dec 14.
2
Allergic disorders and their risk factors in primary Sjögren's syndrome.原发性干燥综合征中的过敏性疾病及其危险因素。
World Allergy Organ J. 2023 Jan 27;16(2):100745. doi: 10.1016/j.waojou.2023.100745. eCollection 2023 Feb.
3
Alu RNA induces NLRP3 expression through TLR7 activation in α-1-antitrypsin-deficient macrophages.Alu RNA 通过激活 TLR7 在缺乏α-1-抗胰蛋白酶的巨噬细胞中诱导 NLRP3 表达。

本文引用的文献

1
The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.Ro60自身抗原结合内源性逆转录元件并调节炎症基因表达。
Science. 2015 Oct 23;350(6259):455-9. doi: 10.1126/science.aac7442. Epub 2015 Sep 17.
2
Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus.Ro60 需要 Y3 RNA 进行细胞表面暴露，并与新生儿狼疮的心脏表现相关的炎症有关。
J Immunol. 2013 Jul 1;191(1):110-6. doi: 10.4049/jimmunol.1202849. Epub 2013 May 22.
3
Long-term Ro60 humoral autoimmunity in primary Sjögren's syndrome is maintained by rapid clonal turnover.
JCI Insight. 2022 Jun 22;7(12):e158791. doi: 10.1172/jci.insight.158791.
4
Machine Learning for the Identification of a Common Signature for Anti-SSA/Ro 60 Antibody Expression Across Autoimmune Diseases.机器学习在识别跨自身免疫性疾病的抗 SSA/Ro 60 抗体表达的常见特征中的应用。
Arthritis Rheumatol. 2022 Oct;74(10):1706-1719. doi: 10.1002/art.42243. Epub 2022 Aug 25.
5
Role of the Innate Immunity Signaling Pathway in the Pathogenesis of Sjögren's Syndrome.固有免疫信号通路在干燥综合征发病机制中的作用。
Int J Mol Sci. 2021 Mar 17;22(6):3090. doi: 10.3390/ijms22063090.
6
The Sophisticated Transcriptional Response Governed by Transposable Elements in Human Health and Disease.转座元件调控的人类健康与疾病中的复杂转录反应。
Int J Mol Sci. 2020 Apr 30;21(9):3201. doi: 10.3390/ijms21093201.
7
The Endogenous Plasma Small RNAome of Rheumatoid Arthritis.类风湿关节炎的内源性血浆小分子RNA组
ACR Open Rheumatol. 2020 Feb;2(2):97-105. doi: 10.1002/acr2.11098. Epub 2020 Jan 8.
8
Sjögren's syndrome and systemic lupus erythematosus: links and risks.干燥综合征与系统性红斑狼疮：联系与风险
Open Access Rheumatol. 2019 Jan 29;11:33-45. doi: 10.2147/OARRR.S167783. eCollection 2019.
原发性干燥综合征中 Ro60 体液自身免疫的长期存在是由快速克隆转换维持的。
Clin Immunol. 2013 Jul;148(1):27-34. doi: 10.1016/j.clim.2013.03.015. Epub 2013 Apr 4.
4
Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block.Ro60 相关的单链 RNA 通过 TLR 连接将炎症与胎儿心脏纤维化联系起来：自身免疫性相关心脏传导阻滞的新途径。
J Immunol. 2010 Feb 15;184(4):2148-55. doi: 10.4049/jimmunol.0902248. Epub 2010 Jan 20.
5
The subcellular distribution of an RNA quality control protein, the Ro autoantigen, is regulated by noncoding Y RNA binding.一种RNA质量控制蛋白Ro自身抗原的亚细胞分布受非编码Y RNA结合的调控。
Mol Biol Cell. 2009 Mar;20(5):1555-64. doi: 10.1091/mbc.e08-11-1094. Epub 2008 Dec 30.
6
A B cell apotope of Ro 60 in systemic lupus erythematosus.系统性红斑狼疮中Ro 60的B细胞表位
Arthritis Rheum. 2008 Apr;58(4):1125-9. doi: 10.1002/art.23377.
7
The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure.60 kDa Ro自身抗原成为焦点：基于结构解释表位作图实验
Autoimmun Rev. 2006 Jul;5(6):367-72. doi: 10.1016/j.autrev.2005.10.004. Epub 2005 Nov 15.
8
"Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.狼疮自身抗原Sm/RNP和Ro 60的RNA成分的“内源性佐剂”活性。
Arthritis Rheum. 2006 May;54(5):1557-67. doi: 10.1002/art.21819.
9
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.小核核糖核酸内自身抗原结合位点介导的免疫刺激涉及Toll样受体7和8。
J Exp Med. 2005 Dec 5;202(11):1575-85. doi: 10.1084/jem.20051696.
10
Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis.细胞凋亡过程中细胞质小Y RNA的快速核酸酶解降解。
J Biol Chem. 1999 Aug 27;274(35):24799-807. doi: 10.1074/jbc.274.35.24799.